Enhancing Prediction of Adverse Pregnancy Outcomes in Africa Through Partnerships and Innovation

Conditions studied

Fetal Growth Restriction (FGR), Preterm Birth, Still Births, Abruptio Placentae, Rupture of Membranes; Premature, Preeclampsia

About this study

Pregnancy complications such as pre-eclampsia (high blood pressure during pregnancy), poor fetal growth, unexplained stillbirth, and spontaneous preterm birth are major causes of illness and death for mothers and babies in sub-Saharan Africa. These conditions, known as the Great Obstetrical Syndromes, are thought to result from problems with the development of the placenta early in pregnancy. However, there is limited information from African populations to help identify women at risk or improve prevention and treatment. This study will enroll 4,000 first-time pregnant women in Uganda before 18 weeks of pregnancy and follow them throughout pregnancy until delivery. Participants will attend routine study visits where information about their health, pregnancy, and social circumstances will be collected. Physical examinations, ultrasound scans, and blood samples will be obtained at several time points during pregnancy, and blood and placental samples will be collected at birth. Some samples will be analyzed during the study, while others will be stored for future research with appropriate ethical approval. The study will examine which clinical, biological, and social factors are associated with pregnancy complications. Researchers will use statistical methods and artificial intelligence (AI) techniques to identify patterns that may help predict which women are at increased risk of developing these conditions. The knowledge gained from this study may support the development of better screening tools and strategies for preventing pregnancy complications, improve maternal and newborn health outcomes in Uganda and other African settings, and establish a valuable biobank to support future maternal and newborn health research.

Primary outcomes

• Number of Participants who Develop Pre-eclampsia (From recruitment until the date of first documented hypertension plus proteinuria or date of delivery whichever came first)
• Number of Participants who Experience Spontaneous Preterm Birth (From recruitment to date of delivery before 37 completed weeks of gestation)
• Number of Participants who Develop Fetal Growth Restriction (From recruitment to date of delivery)
• Number of Participants who give birth to a stillbirth. (From recruitment to date of delivery)

Eligibility information

Study locations

• Mulago Specialised Women and Neonatal Hospital, Kampala, 22081 Uganda
• Kawempe National Referral Hospital, Kampala, 3253 Uganda