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Anterior Segment Anatomy Assessed by Swept-Source OCT in Ocular Surgery Patients

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ClinicalTrials.gov IDNCT07903454

PhaseNot Applicable

Enrollment500

SponsorNanfang Hospital, Southern Medical University

Age18 Years – 90 Years

SexALL

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Conditions studied

Cataract, Primary Angle-Closure Glaucoma

About this study

This observational study aims to evaluate ocular anatomical parameters in patients undergoing anterior segment surgery using swept-source optical coherence tomography (SS-OCT). Anterior segment surgery, including procedures involving the cornea, lens, and other anterior eye structures, may be associated with changes in ocular anatomy. SS-OCT is a non-invasive imaging technique that provides detailed images of the anterior structures of the eye and allows quantitative assessment of ocular anatomical parameters. Patients undergoing anterior segment surgery at Nanfang Hospital, Southern Medical University, will be included in this study. SS-OCT will be used to assess ocular anatomical parameters, and the collected measurements will be analyzed to characterize anatomical features and explore potential differences among patients undergoing different types of anterior segment surgery. The findings of this study may improve understanding of ocular anatomical characteristics in patients undergoing anterior segment surgery and provide useful information for clinical assessment and surgical management.

Interventions

Diagnostic Test: Ocular anatomical parameters will be measured using a swept-source optical coherence tomography (SS-OCT) device (CASIA2; Tomey Corporation, Nagoya, Japan). The imaging examination will be used to asse — Ocular anatomical parameters will be assessed using a swept-source optical coherence tomography (SS-OCT) device (CASIA2; Tomey Corporation, Nagoya, Japan). This non-invasive imaging examination provides detailed visualization and quantitative measurements of anterior segment structures. The collected imaging data will be used to evaluate ocular anatomical characteristics and investigate their associations with relevant clinical factors in patients undergoing anterior segment surgery. Surgical treatment decisions will follow routine clinical practice and will not be assigned by the study protocol.

Primary outcomes

Change in Anterior Chamber Depth (ACD) (Preoperative baseline; postoperative day 1, week 1, month 1, and month 3)
Change in Anterior Chamber Width (ACW) (Preoperative baseline; postoperative day 1, week 1, month 1, and month 3)
Change in Anterior Chamber Volume (ACV) (Preoperative baseline; postoperative day 1, week 1, month 1, and month 3)
Change in Angle Opening Distance at 500 μm (AOD500) (Preoperative baseline; postoperative day 1, week 1, month 1, and month 3)
Change in Trabecular-Iris Space Area at 500 μm (TISA500) (Preoperative baseline; postoperative day 1, week 1, month 1, and month 3)
Change in Trabecular-Iris Angle at 500 μm (TIA500) (Preoperative baseline; postoperative day 1, week 1, month 1, and month 3)
Change in Iris Curvature (IC) (Preoperative baseline; postoperative day 1, week 1, month 1, and month 3)

Eligibility information

Inclusion Criteria: * Voluntary provision of written informed consent. * 18≤Age≤90 years. * Patients diagnosed by an ophthalmologist with cataract, primary angle-closure disease, or other anterior segment disorders requiring anterior segment surgery. * Availability of complete or accessible preoperative and postoperative clinical records and ophthalmic examination data. Exclusion Criteria: * Follow-up duration of less than 3 months. * Substantial missing ophthalmic examination or perioperative data that prevents the required study analyses. * Inability to obtain valid anterior segment imaging data due to severe corneal opacity, poor ocular fixation, inadequate cooperation, or other related factors. * Presence of severe ocular trauma, intraocular tumors, severe corneal disease, active intraocular inflammation, or other ocular conditions that may substantially affect anterior segment structural assessment. * History of complex intraocular surgery that may significantly alter anterior segment anatomy and is considered unsuitable for inclusion by the investigator. * Other conditions considered by the investigator to make the patient unsuitable for participation in the study.

Study locations

Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515 China

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-11-10.