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Inclusion Criteria: 1. Voluntarily participate in clinical trials, understand the nature of the study and any risks involved in participation, sign an informed consent form, and be willing to comply with the requirements specified in the protocol; 2. Aged between 18 and 50 years (inclusive), healthy volunteers; 3. Body mass index (BMI) between 18-26 kg/m² (inclusive), with minimum weight requirements of 50 kg (inclusive) for males and 45 kg (inclusive) for females; 4. In generally good health, as determined by the investigator based on medical history, surgical history, complete physical examination, vital signs measurements, laboratory tests, 12-lead electrocardiogram (ECG), and chest X-ray results, with no evidence of clinical disease and confirmed to be healthy; 5. For females of childbearing potential: Agree to use highly effective contraception (e.g., intrauterine device, hormonal contraceptives, or condoms) throughout the study and for 3 months after the last dose, with a negative serum pregnancy test at screening. For males: Agree to use effective contraception (specific methods detailed in Appendix 5) during the study and for 3 months after the last dose. Exclusion Criteria: 1. Known allergy to aldosterone synthase inhibitors or any components/excipients of the investigational drug; 2. The clinically significant endocrine, metabolic, cardiovascular, respiratory, gastrointestinal, liver and kidney, nervous system (including the history of seizures) or any significant history of mental illness or mental disorder, or clinically significant diseases, conditions or other evidence, which the researcher believes will pose risks to the safety of the subjects or interfere with the development, conduct or completion of the study; 3. Any known diseases or conditions that may interfere with drug absorption, distribution, metabolism or excretion (such as dysphagia or gastrointestinal diseases that affect drug absorption, or previous gastric surgery, vagotomy, enterotomy or any surgery that may interfere with gastrointestinal peristalsis, PH or absorption, etc.); 4. Vaccination with active or attenuated vaccine within 4 weeks before screening or during the trial (except influenza vaccine); 5. Drinking excessive amounts of tea, coffee and/or caffeinated beverages (more than 8 cups, 1 cup =250mL) per day, or drinking tea, coffee and/or caffeinated beverages within 48 hours before drug administration, or unable to stop drinking during the trial; Had a history of long-term consumption of a beverage or food rich in xanthine or grapefruit, or had taken any product rich in xanthine or grapefruit within 48 hours before administration； 6. Smokers or those who used nicotine products excessively (≥5 cigarettes per day on average) in the 3 months before screening or who were unable to stop using any tobacco or nicotine-based products (snus, chewing tobacco, cigars, pipes, or nicotine-replacement products) during the trial； 7. Participants who had participated in a clinical trial of another drug and had taken any investigational drug within 3 months before the first dose； 8. Use of corticosteroids within 3 months prior to the first dose； 9. Within 3 months before the first dose of blood donation or blood loss≥400 ml, blood transfusion or use of blood products, or plans to test during or within 30 days after the last drug blood donors； 10. Were heavy drinkers or regular drinkers in the 3 months before screening, which was defined as having consumed an average of 14 standard units of alcohol per week (one unit of alcohol =285mL of beer or 25mL of spirits or 125mL of wine), had a positive alcohol breath test at screening, or were unable to stop using any alcohol-containing product during the trial; 11. Drug abuse screening is positive or in the past five years has a history of substance abuse or screening before 3 months used drugs； 12. Blood pressure in the range of 90-140mmHg (systolic) or 50-90mmHg (diastolic) or pulse rate in the range of 50-100 beats/min during the screening period;Or postural hypotension (systolic blood pressure decreased ≥20mmHg or diastolic blood pressure decreased ≥ 10mmHg while standing)； 13. During the screening period, any one of the infectious disease screening results of hepatitis B surface antigen (HBsAg), hepatitis C (HCV) antibody, HIV antibody and treponema pallidum antibody was positive； 14. The presence of uncontrolled active bacterial, viral, fungal, rickettsial, or parasitic infections, unless treated prior to study treatment and had returned to normal； 15. Use of any medication (including prescription drugs, over-the-counter drugs, herbal medicines, functional vitamins, supplements, etc.) within 14 days before the first dose (or within 5 half-lives of the drug used, whichever is longer) that the investigator considers may affect the evaluation of the pharmacokinetic characteristics of the study drug or interfere with the study procedures or affect the safety assessment； 16. Serum potassium level \<3.5 mmol/L or ≥5.0 mmol/L at screening and admission； 17. Subjects with aspartate aminotransferase (AST), alanine aminotransferase (ALT), or total bilirubin \>1.5 times the upper limit of normal (ULN) at screening or admission； 18. Abnormal renal function (estimated glomerular filtration rate \< 90 mL/ minute /1.73m2 using the Chronic Kidney Disease Epidemiology Collaboration \[CKD-EPI\] equation, as described in Appendix 1: CKD-EPI equation)； 19. Family history of long or short QT syndrome, history of syncope or torsdes pointes, heart failure, or clinically significant/symptomatic bradycardia, and risk factors including uncontrolled hypokalemia, hypocalcemia, or hypomagnesemia.For participants in the QT/QTc study, use of antiarrhythmic drugs, inotropic drugs, beta-blockers, calcium-channel blockers, quinolones, and other drugs with a risk of prolonging the QT/QTc interval or causing torsdes pointes within 4 weeks before the first dose (see Appendix 3 for details); And prolonged QTcF interval (\> 450msec)； 20. Clinically significant abnormal ECG findings at screening or admission as judged by the investigator; Strenuous physical training or excessive exercise (e.g., long-distance running, weight lifting, or any physical activity to which the participant is not accustomed) from 7 days before administration until the end of the study； 21. The investigator judged that the subject had other conditions that were not suitable for participation in this study.

Inclusion Criteria: * Has a confirmed diagnosis of Type 2 diabetes mellitus (T2DM) * Has body mass index (BMI) between 18 and 40 kg/m\^2, inclusive Exclusion Criteria: * Has Type 1 diabetes mellitus or secondary types of diabetes * Has a history of congestive heart failure (New York Heart Association \[NYHA\] Class 3 or 4) * Has history of myocardial infarction, uncontrolled arrhythmias, cardiac revascularization, angina, unstable peripheral arterial disease and/or stroke * Has history of cancer (malignancy) * Has positive test(s) for hepatitis B surface antigen (HBsAg), hepatitis C antibodies, or human immunodeficiency virus (HIV) * Has a history of gastrointestinal (GI) disease which might affect food and drug absorption, or has had gastric bypass or similar surgery

Inclusion Criteria: * High school students ages 13-18 years. * Attending a participating rural high school in Schuylkill County, Pennsylvania. * Presenting with self-reported symptoms of depression, anxiety, or stress. Must have a t-score ≥ 55 on one or more of the following three measures: i. PROMIS Emotional Distress Depression short-form questionnaire ii. PROMIS Emotional Distress Anxiety short-form questionnaire iii. PROMIS Psychological Stress Experiences short-form questionnaire * English-speaking (to ensure comprehension of CBT materials and assessments). Exclusion Criteria: * Diagnosis of a psychotic disorder, bipolar disorder, intellectual disability, or seizure disorder. * Assessed to be at high risk for suicide or requiring immediate crisis intervention. * Inability to participate in school-based sessions due to scheduling conflicts or behavioral concerns.

Inclusion Criteria: 1. Age: 18-65 years old, male or female; 2. Three groups of patients will be enrolled in the study: 1. Essential Hypertension Grade 1 (Low Risk) - Antihypertensive Medication-Naive Group: No other cardiovascular risk factors or disease history, with systolic blood pressure (SBP) ≥140 mmHg and \<160 mmHg and/or diastolic blood pressure (DBP) ≥90 mmHg and \<100 mmHg; 2. Essential Hypertension - Refractory Hypertension Group: Meeting one of the following conditions after intensive lifestyle intervention plus taking 3 different types of antihypertensive drugs (including thiazide diuretics) for ≥4 weeks, with each drug at the maximum dose or maximum tolerated dose: Clinic blood pressure ≥140/90 mmHg and 24-hour average ambulatory blood pressure ≥130/80 mmHg, or average home blood pressure ≥135/85 mmHg; or blood pressure can only be controlled below 140/90 mmHg with ≥4 types of antihypertensive drugs; 3. Neurogenic Orthostatic Hypotension (nOH) Group: A decrease in SBP ≥20 mmHg and/or DBP ≥10 mmHg within 3 minutes of the head-up tilt test (HUTT) and/or standing activity; 3. BMI: 18-30; 4. After being informed of the potential risks, the patient agrees to participate in this study and signs the informed consent form (ICF). Exclusion Criteria: 1. Patients with secondary hypertension; 2. Patients with intracranial structural lesions (e.g., infarcts, vascular malformations, space-occupying lesions, etc.); 3. Pregnant women; 4. Individuals unable to cooperate due to mental illness or other reasons; 5. Those who have participated in other clinical studies within the past 3 months; 6. Patients who apply to withdraw from this clinical study for any reason; 7. Patients with cardiac insufficiency; 8. Patients excluding those with white coat effect; 9. Individuals with a high risk of cerebrovascular disease confirmed by transcranial magnetic resonance imaging (MRI).

Inclusion Criteria: 1. Patients must have signed a written informed consent form prior to any trial specific procedures; 2. Patients must be ≥18 years old; 3. Histologically confirmed or radiologically documented unresectable locally advanced or metastatic cancer (Breast, Urothelial, Non small Cell Lung or Gastric) with an indication to receive an Antibody-Drug Conjugate (ADC) approved or accessible through an early access program; 4. Patients must have at least 2 tumor lesions (primary tumor can be included): at least one measurable tumor lesion for tumor evaluation according to response evaluation criteria in solid tumors (RECIST) V1.1 and at least one tumor lesion other than bone and brain for biopsy; 5. Patients must have a metastatic or locally advanced tumor site easily accessible to biopsy (with exception of bone and brain metastasis) and must have agreed to perform pretreatment and post-treatment biopsies; an archival pre-treatment biopsy may be used if it was collected within one month of enrolment, if no anticancer therapy was administered after the biopsy and if sufficient material is available for research; 6. Life expectancy must be ≥12 weeks according to the discretion of the investigator; 7. ECOG performance status ≤ 2; 8. Patients must have adequate hematologic and organ function, compatible with ADC administration, as per drug-specific recommendations; 9. Women of childbearing potential and male patient must agree to use adequate contraception for the duration of trial participation and up to 7 months after completing treatment for women and up to 4 months for men; 10. Patients must be affiliated to a social security system (or equivalent); 11. Patients must be willing and able to comply with the protocol for the duration of the trial; 12. Patients must consent to the use of their collected tumor specimen, as well as, blood samples as detailed in the protocol for future scientific research, which includes but is not limited to DNA, RNA, and protein-based biomarker analysis. Exclusion Criteria: 1. Patients treated with an antibody drug conjugate in a curative setting; 2. Patients who did not consent to sample use; 3. Presence of another progressive pathology with short-term life-threatening prognosis; 4. Patients undergoing concurrent treatment for a malignancy or hematologic disorder distinct from the indication for which the ADC is being administered. 5. Patients with inadequate washout period prior to Cycle 1 Day 1, defined as: * Whole brain radiation therapy \<14 days or stereotactic brain radiation therapy \<7 days. * Any cytotoxic chemotherapy, investigational agents or other anticancer drug(s) (including another ADC) from a previous cancer treatment regimen or clinical study (other than epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI)), \<14 days or 5 half-lives, whichever is longer. * Immune checkpoint inhibitor therapy \<21 days. * Hormonal therapy \<21 days. * Major surgery (excluding placement of vascular access) \<28 days. * Radiotherapy treatment to more than 30% of the bone marrow or with a wide field of radiation \<28 days or palliative radiation therapy \<14 days. 6. Female participant who is pregnant, breastfeeding, or planning to become pregnant while enrolled in this study or within 90 days after the final administration of study treatment; 7. Person deprived of their liberty or under protective custody or guardianship.

Inclusion Criteria: 1. Signed informed consent and compliant. 2. Age 18-70 years. 3. ECOG PS 0-1; life expectancy \>6 months. 4. Histologically/cytologically confirmed primary breast cancer. 5. Primary tumor \>2cm (by local standard assessment) or node-positive disease. 6. AJCC 8th edition Stage II-IIIC (T2-T4 any N, or any T N1-3 M0) unilateral invasive breast cancer. 7. Confirmed HER2-positive (IHC 3+ or ISH positive). Note: Patients with HER2-negative primary tumor but HER2-positive nodes are eligible. 8. At least one measurable lesion per RECIST 1.1. 9. Agreement to undergo surgery if indicated after neoadjuvant therapy. 10. Willing to provide tumor tissue for biomarker analysis. 11. Adequate organ function: * ANC ≥1.5×10⁹/L; PLT ≥100×10⁹/L; HGB ≥90 g/L * Albumin ≥30 g/L -. TBIL ≤1.5×ULN; ALT/AST ≤2.5×ULN (≤5×ULN if liver metastases); AKP ≤2.5×ULN * Creatinine ≤1.5×ULN * PT/APTT/INR ≤1.5×ULN (or within therapeutic range if on anticoagulants) 12. For women of childbearing potential: negative pregnancy test within 7 days prior to treatment; must not be breastfeeding. 13. Use of highly effective contraception during and for 3 months after treatment. Exclusion Criteria: 1. Stage IV metastatic breast cancer or patients deemed ineligible for curative surgery after neoadjuvant therapy. 2. Inflammatory breast cancer. 3. Other malignancies within 3 years, except: those treated with surgery alone and disease-free for 5 years; cured cervical carcinoma in situ, non-melanoma skin cancer, or superficial bladder cancer \[Ta, Tis, T1\]. 4. Prior anti-tumor therapy (chemotherapy, endocrine, anti-HER2) or breast surgery for breast cancer within 3 years (excluding diagnostic biopsy). 5. Major surgery or significant traumatic injury within 28 days before treatment (excluding diagnostic biopsy). 6. Active or history of autoimmune diseases (e.g., autoimmune hepatitis, interstitial pneumonia, uveitis, enteritis, hypophysitis, vasculitis, nephritis, hyperthyroidism). Exceptions: vitiligo, childhood asthma in complete remission without intervention in adulthood. 7. Current use of immunosuppressants or systemic corticosteroids (\>10mg/day prednisone equivalent) within 2 weeks prior to enrollment. 8. History of severe hypersensitivity to monoclonal antibodies. 9. Known central nervous system metastases. 10. Poorly controlled concurrent illnesses, including: * Uncontrolled hypertension (SBP\>150 or DBP\>100 mmHg on medication) or history of hypertensive crisis/encephalopathy. * History of heart failure or systolic dysfunction (LVEF \<55%). * Myocardial ischemia/infarction (≥Grade 2), arrhythmias (QTc≥450ms M, ≥470ms F), or CHF (≥NYHA Class II). * Angina requiring medication; clinically significant valvular disease. * Active HCV (RNA+), HIV+, syphilis (unless cured), or HBV (HBsAg+ with HBV DNA≥2000 IU/ml or positive qualitative test). 11. Use of Chinese patent medicines with approved anti-tumor indications within 2 weeks prior to treatment. 12. Significant bleeding tendency or clinical bleeding within 3 months; positive fecal occult blood requiring gastroscopy if persistently positive. 13. Tumor invasion or high risk of invasion into major vessels, potentially causing fatal hemorrhage. 14. Pleural, peritoneal, or pericardial effusion requiring drainage (eligible if stable after drainage). 15. Arterial/venous thromboembolic events within 6 months (e.g., CVA, TIA, DVT, PE). 16. Known hereditary or acquired bleeding/thrombotic tendencies (e.g., hemophilia). 17. Severe, non-healing wounds, active ulcers, or untreated fractures. 18. Urinary protein ≥++ confirmed by 24-hour urine protein \>1.0g. 19. Active infection, unexplained fever ≥38.5°C within 7 days, or baseline WBC \>15×10⁹/L. 20. History of drug abuse or psychiatric disorders. 21. Participation in other anti-tumor drug trials within 4 weeks. 22. Allergy to any study drug or its components. 23. Any condition deemed by the investigator to pose a safety risk or affect study completion.

Inclusion Criteria: * Women aged 30 to 65 years. * Previous diagnosis of breast cancer (stages I-III) confirmed by medical records. * Completion of primary oncological treatment (surgery, radiotherapy, chemotherapy, and/or hormone therapy) at least 3 months before enrollment. * Absence of active cancer or evidence of recurrence. * Medical clearance to perform physical exercise. * Willingness to participate in dietary and/or exercise interventions for 12 weeks. * Ability to attend evaluation and intervention sessions and comply with study procedures. * Signed written informed consent. Exclusion Criteria: * Active cancer, metastasis, or ongoing chemotherapy or radiotherapy. * Severe cardiovascular, respiratory, renal, hepatic, or metabolic disease that contraindicates exercise. * Musculoskeletal or neurological conditions limiting participation in physical activity. * Severe psychiatric disorders or cognitive impairment affecting adherence to the intervention. * Current participation in another clinical trial or structured lifestyle intervention. * Use of dietary supplements, appetite regulators, or pharmacological agents affecting metabolism during the study period. * Pregnancy, breastfeeding, or intention to become pregnant during the study. * Inability to comply with the intervention schedule or follow-up assessments.

Inclusion Criteria: * Aged ≥18 years; * No current clinical diagnosis of a mental health disorder; * No mental-health treatment or psychotropic medication initiated within the past 3 months; * Able to access the internet and provide informed consent. Exclusion Criteria: * Current engagement with a mental health professional or therapy; * Inability to access the DMHI and OPS platform, or inability to provide informed consent; * PHQ-9 score ≥15 or GAD-7 score ≥15 at baseline (these participants will be referred to specialist services and excluded from further study participation) Confirmation of eligibility to participate. To comply with local regulations and ensure participant safety, a qualified and appropriately licensed specialist, affiliated with the institution will participate in screening of the participants recruitment results and carrying out decisions on whether to include or exclude the participant from the study based on degree of severity in the underlying psychological or psychiatric condition. The decision to exclude participants will be made based on safety considerations, need for emergency psychiatric help, compliance assumption and perceived efficacy. Withdrawal. Participation is voluntary. All enrolled participants are free to withdraw from the study at any time with or without notice to study personnel. Risk to self and/or others. During enrollment and study course, participants will be screened for severity of symptoms. If our participating specialist identifies a risk to self or others, appropriate actions will be taken to contact the authorities and local law representatives according to European and Local Law. Sample size estimates. For two groups and a dichotomous endpoint (improvement or no improvement) and an anticipated incidence of 45% in the intervention group and 75% in the control group, at a 95% confidence level and 5% margin of error, power of 80% and enrolment ratio of 1, a sample size of 82 participants was chosen for this RCT (41 in intervention group, 41 in control group).

1. Age≥18years. 2. Diagnosis of type 2 diabetes mellitus (per treating physician or ADA criteria). 3. CKDstage3:eGFR30-59mL/min/1.73 m² on at least two measurements ≥3 months apart OR established diagnosis in medical record. 4. Clinically stable (no AKI, no hospitalization for cardiovascular event in past 3 months). 5. Ableandwilling to provide informed consent.

Inclusion Criteria: * Female patients aged ≥18 years. * Diagnosed with unifocal, operable invasive breast carcinoma. * Suitable for breast-conserving surgery. Criteria: Exclusion criteria: -Contraindication of Breast-Conserving Surgery.

Inclusion Criteria: * Individuals who voluntarily participate in this study and whose parents or guardians voluntarily sign the informed consent form. * Individuals capable of cooperating to complete measurements of all indicators throughout the entire intervention cycle. Exclusion Criteria: * Individuals with eye conditions such as glaucoma, strabismus, or anisometropia. * Wearers of orthokeratology lenses. * Individuals who have undergone refractive surgery. * Individuals who have taken weight-loss medications or undergone weight-loss surgery. * Individuals with obesity caused by endocrine disorders or medication side effects. * Individuals with mental health disorders. * Individuals currently taking medications for mental health disorders.

Inclusion Criteria: * Women aged ≥18 years. * Histologically confirmed invasive, early-stage breast carcinoma scheduled for adjuvant radiotherapy. * Receiving total radiation dose of 40 Gy for 15 sessions. Exclusion Criteria: * Prior exposure to radiotherapy. * Inflammatory or metastatic breast carcinoma. * Patients with connective tissue disorders. * Patients with skin inflammatory diseases (e.g. ectopic dermatitis). * Patients with known allergy or hypersensitivity to alpha lipoic acid. * Concomitant use of nonsteroidal anti-inflammatory drugs, corticosteroids, or antioxidant medications. * Patients who will fail to sign the written consent.

Inclusion Criteria: * Adults ≥18 years. * Histologically confirmed breast cancer with planned (neo)adjuvant anthracycline-based chemotherapy (4 cycles of epirubicin + cyclophosphamide or doxorubicin + cyclophosphamide). * Eligible to start dapagliflozin or placebo prior to or at initiation of chemotherapy. * Able to perform baseline echocardiography, vascular ultrasound (FMD and carotid stiffness), 6-minute walk test, and biomarker sampling. * Willing and able to provide written informed consent. Exclusion Criteria: * Known heart failure (any prior diagnosis of HF). * Clinically significant valvular heart disease. * Prior exposure to chemotherapy or radiotherapy to the left chest. * Type 1 diabetes mellitus. * Symptomatic hypotension. * History of recurrent urinary tract infections. * History of diabetic ketoacidosis or ketonemia. * Severe hepatic impairment (ALT, AST, ALP \>3× upper limit of normal). * Severe renal impairment (eGFR \<20 mL/min/1.73 m²). * Known allergy or intolerance to SGLT-2 inhibitors. * Any use of SGLT-2 inhibitor therapy within 3 months prior to enrollment. * Pregnancy or breastfeeding. * Any condition that, in the investigator's judgment, could interfere with study participation, safety, or completion.

Inclusion Criteria: 1. Adults aged 18 years or older with full legal capacity. 2. Clinically diagnosed with Type 2 Diabetes Mellitus and receiving ongoing outpatient care. 3. Able to read and understand Chinese questionnaires and complete self-administered forms. 4. Understand the study purpose and procedures and provide written informed consent. Exclusion Criteria: 1. Presence of major psychiatric disorders (e.g., schizophrenia, bipolar disorder, major depressive disorder). 2. Moderate to severe cognitive impairment or dementia, as assessed by the clinical physician, making it impossible to complete the questionnaires. 3. Currently experiencing acute diabetic complications (e.g., diabetic ketoacidosis, hyperosmolar hyperglycemic state) or hospitalization. 4. Severe language or other communication barriers preventing expression of consent or understanding of study content.

Inclusion Criteria: * 18-65 years of age * ASA I-II-III risk groups * Patients with informed consent * Patients undergoing breast cancer surgery Exclusion Criteria: • Ages \<18 and \>65 * ASA ≥ IV * History of allergy to local anesthetics * Known coagulation disorders * Infection near the insertion site * Chronic analgesic use * Patients with diabetes mellitus and those receiving neoadjuvant chemotherapy (due to potential impairment of pain sensation) * Body mass index \>30 * Dementia or confusion * Lack of cooperation

Inclusion Criteria: * Between 10 and 20 years of age; * Diagnosis of major depressive disorder (MDD) or bipolar disorder (BD) according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV). Diagnosis is assessed using the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I) for participants aged ≥18 years, or the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime version (K-SADS-PL) for participants aged \<18 years; * Current moderate to severe depressive episode, defined as Hamilton Depression Rating Scale (HAMD) score ≥17; * Participants and 1 or 2 parents (patients' age\< 18 years old) provide informed consent after the detailed description of the study. Exclusion Criteria: * Prior treatment with repetitive transcranial magnetic stimulation (rTMS), transcranial direct current stimulation (tDCS), electroconvulsive therapy (ECT), or standard psychological therapy within 6 months prior to screening; * Comorbidity with other DSM-IV Axis I disorders or personality disorders; * Judged clinically to be at serious risk of suicide; * Diabetes mellitus, hypertension, vascular and infectious diseases and other major medical comorbidities; * Unstable medical conditions, e.g., severe asthma; Neurological disorders, e.g., history of head injury with loss of consciousness for ≥ five minutes, cerebrovascular diseases, brain tumors and neurodegenerative diseases; * Mental retardation or autism spectrum disorder; * Contraindications to MRI (e.g., severe claustrophobia, pacemakers, metal implants); * Current drug or alcohol abuse or dependence; * Pregnant or lactating females.

Inclusion Criteria: * Adults aged ≥18 years. * Diagnosis of mild autonomous cortisol secretion (MACS) defined by: * Serum cortisol \>1.8 µg/dL after 1 mg overnight dexamethasone suppression test (DST). * Presence of adrenal adenoma confirmed by imaging (CT or MRI). * Ability to provide informed consent. * Willingness to undergo study procedures including DEXA scan and laboratory assessments. Exclusion Criteria: * Known diagnosis of Cushing's syndrome or overt hypercortisolism. * Current or recent (within 3 months) treatment with glucocorticoids or medications affecting cortisol production (e.g., ketoconazole, metyrapone). * Severe hepatic impairment or renal failure. * Pregnancy or breastfeeding. * Known allergy or contraindication to osilodrostat (Isturisa). * Participation in another interventional clinical trial within the last 30 days. * Any medical or psychiatric condition that, in the investigator's judgment, may interfere with study participation or safety.

Inclusion Criteria: 1. Aged between 18 and 75 years inclusive, regardless of gender; 2. Body Mass Index (BMI) ≥ 24 kg/m²; 3. Diagnosed with essential hypertension, either untreated or currently receiving antihypertensive medication; 4. For patients who have not received antihypertensive medication in the past 3 months, the msSBP at the screening visit must be ≥ 150 mmHg and \< 180 mmHg; 5. For patients currently receiving antihypertensive medication, the msSBP at the screening visit must be ≥ 140 mmHg and \< 180 mmHg; and at the visit after the washout period, the msSBP must be ≥ 150 mmHg and \< 180 mmHg. Exclusion Criteria: 1. Severe hypertension (msSBP ≥ 180 mmHg and/or msDBP ≥ 110 mmHg); malignant hypertension, etc.; 2. History of or diagnostic evidence for obstructive sleep apnea (OSA); 3. History of angioedema; 4. History of or diagnostic evidence for secondary hypertension; 5. Hypertension complicated with the following conditions: acute coronary syndrome, myocardial infarction, percutaneous coronary intervention, or stroke occurring within 12 months; New York Heart Association (NYHA) Class II-IV heart failure, large aortic aneurysm or aortic dissection, atrioventricular block of degree II or higher, sick sinus syndrome, bradycardia (heart rate \< 50 beats per minute) or other arrhythmias requiring antiarrhythmic drugs, as well as severe diseases such as epilepsy and syncope; 6. Clinically significant abnormalities in laboratory tests (serum potassium \> 5.5 mmol/L or \< 3.5 mmol/L; serum alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST) \> 2.5 × upper limit of normal (ULN); serum creatinine \> 1.5 × ULN); 7. Type 1 diabetes mellitus and type 2 diabetes mellitus with poor glycemic control (glycated hemoglobin (HbA1c) \> 8.0%); 8. Patients currently using drugs with weight-loss effects such as glucagon-like peptide-1 (GLP-1) and sodium-glucose cotransporter 2 (SGLT-2) inhibitors; 9. Patients undergoing hemodialysis or strict salt-restriction therapy; 10. Known or suspected allergy to sacubitril/allisartan, sacubitril/valsartan sodium, amlodipine, or related drugs; 11. Patients deemed unsuitable for participation in the study by the investigator.

Inclusion Criteria: * Clinically stable, mild atopic asthma (FEV1 ≥70% predicted) * Established allergy confirmed by positive skin prick test at screening * Willing and able to perform lung function tests and other study-related procedures * Participants of childbearing potential must consent to use a method of highly-effective contraception in addition to a condom during the study and for at least 90 days following the end of study or last investigational product administration, whichever is later Exclusion Criteria: * Concomitant diagnosis of a clinically important pulmonary disease other than asthma * Use of corticosteroids, immunosuppressives, or anti-inflammatory medications that interfere with inhaled challenges or inflammation, or chronic use of any other medication for treatment of allergic asthma * History or current medical condition contraindicating methacholine challenge Note: Additional inclusion/exclusion criteria may apply per protocol.

Key Inclusion Criteria: 1. Medical history of type 2 diabetes and receiving medical therapy or lifestyle interventions for glucose management 2. Hemoglobin A1C (HbA1c) of 6.5 to 10% at screening 3. eGFR 30 to 90 mL/min/1.73 m\^2 using 2021 Chronic Kidney Disease-Epidemiology Collaboration-Estimated Glomerular Filtration Rate using Creatinine and Cystatin C (CKD-EPI eGFRcr-cys) equation at screening 4. Albuminuria: Urine Albumin to Creatinine Ratio (UACR) of 500 to 5000 mg/g at screening Key Exclusion Criteria: 1. Known medical history or clinical evidence indicative of non-diabetic renal disease 2. Renal disease that required treatment with systemic immunosuppressive therapy, or a history of dialysis or renal transplant 3. Medically unstable as assessed by the investigator 4. Hospitalization (ie, \>24 hours) within 30 days of the screening visit NOTE: Other Protocol-Defined Inclusion/Exclusion Criteria Apply