Find Clinical Trials

Inclusion Criteria: Subjects must meet all of the following criteria to be eligible for participation in the study: 1. Age ≥ 21 and ≤ 65 years at time of enrollment. 2. Disease diagnosed 2.1 Diagnosed with T2DM with baseline: 1. Fasting plasma glucose ≥ 140 mg/dl (7.8 mmol/l) and ≤ 270 mg/dL (15 mmol/L) 2. HbA1c levels ≥ 7.0% and ≤ 9.0% (53-75 mmol/mol) 3. Triglyceride level \< 400 mg/dL (4.52 mmol/L) 4. On oral anti-hyperglycemic drug regimen of metformin. Subjects may be on additional oral anti-hyperglycemic drug of a different drug class 5. Years of T2DM ≤ 10 years And / Or 2.2 Diagnosed hypertension with baseline: 1. Office blood pressure of SBP of ≥ 140 mmHg and ≤ 180 mmHg and DBP ≥ 90 mmHg 2. Mean 24-hour ambulatory SBP of ≥ 130 mmHg and ≤ 170 mmHg with ≥ 75% valid readings 3. On stable oral anti-hypertension drug regimen consisting of up to a maximum of three drugs 3. BMI between 27.5 and 40 kg/m2 4. C-peptide testing: non-fasting random or stimulated C-peptide ≥ 2 ng/mL (660 pmol/L) 5. Vessel diameter of 3 mm to 7 mm with a minimum arterial treatable length of 20 mm in one or more of the following arteries: * Renal * Hepatic Exclusion Criteria: 1. T1DM or poorly controlled T2DM (defined as HbA1c \> 9.0% or use insulin as medication to control glucose level). 2. Office diastolic blood pressure \< 90 mmHg. 3. Current use of \> 3 hypertension medications. 4. Currently on beta blockers. 5. One or more documented hyperglycemia episodes requiring hospitalization in the 180-day prior to screening date. 6. Prior evidence of hypoglycemia unawareness or serious hypoglycemia with loss of consciousness or confusion sufficient to prevent self-treatment in last 6 months. 7. BMI \> 40 kg/m2. 8. Diagnosed proliferative retinopathy or evidence of peripheral neuropathy. 9. Lack of appropriate treatment site or anatomy precluding the intervention of the target arteries (renal and hepatic artery). 10. History of prior renal or hepatic artery intervention including balloon angioplasty, stenting, etc. 11. Arterial stenosis \>50% of the normal diameter segment (diameter stenosis, compared to the angiographically normal proximal or distal segment). 12. Any abnormality or disease in one or more of the target arteries that, per the physician assessment, precludes the safe insertion of the guiding catheter (including, but not limited to, artery aneurysm, excessive tortuosity, calcification). 13. Occlusive peripheral vascular disease that would preclude percutaneous femoral access for the procedure. 14. Known or suspected secondary hypertension, such as Cushing's disease or Cushing's Syndrome, hyperaldosteronism, pheochromocytoma, thyroid and parathyroid abnormalities, history of pre-eclampsia, onset of hypertension prior to the age of 18. 15. Use of nonsteroidal anti-inflammatory drugs (NSAIDs) for two or more days per week over the month prior to enrollment. 16. Severe or unstable cardiovascular comorbidities, such as AMI or ACS, cardiac valve stenosis, pulmonary embolism, heart failure with NYHA Class III or IV, chronic atrial fibrillation, primary pulmonary hypertension, COPD. 17. Renal transplant, history of nephrectomy or single kidney, renal tumor/cancer, known non-functioning kidney, unequal renal size (\>2 cm difference in renal length between kidneys associated with a chronic kidney disease or a deterioration of the kidney function), chronic renal deficiency with eGFR ≤ 60ml/min/1.73m2, or on chronic renal replacement therapy. 18. Prior liver transplant. 19. Any organ transplantation procedures are planned in the 365 days following Index Procedure. 20. Gastrointestinal permanent anatomic alteration surgery. 21. Any surgical procedure within 30 days prior to Index Procedure. 22. Currently taking the following medications within 90 days prior to screening and/or there is a need or anticipated need for these medications during the study: 1. Systemic Corticosteroids 2. Anticonvulsants 3. Centrally acting sympatholytics 23. Bleeding disorders, such as bleeding diathesis, thrombocytopenia, and severe anemia. 24. Use of anticoagulation therapy which cannot be discontinued from 7 days before or 14 days after the Index Procedure. 25. Any other condition(s) that would compromise the safety of the Subject or compromise study quality as judged by the investigator. 26. Significant alcohol consumption, defined as more than 2 drink units per day (equivalent to 20 g) in women and 3 drink units per day (equivalent to 30 g) in men, or inability to reliably quantify alcohol intake. 27. Active substance abuse, based on Investigator judgement, including inhaled or injected drugs, within 1 year prior to the initial screening. 28. Significant weight loss within the last 6 months (e.g., \> 10% total body weight loss). 29. Hepatic decompensation defined as the presence of any of the following: 1. Serum albumin less than 3.5 g/dL 2. International normalization ratio (INR) greater than 1.4 (unless due to therapeutic anticoagulants) 3. Total bilirubin greater than 2 mg/dL with the exception of Gilbert syndrome 4. History of esophageal varices, ascites, or hepatic encephalopathy 30. ALT or AST greater than 200 U/L. 31. Diagnosis of liver cirrhosis. 32. Chronic liver or biliary disease of the following etiology: 1. History or diagnosis of Hepatitis B 2. History or diagnosis of Hepatitis C 3. History or diagnosis of current active autoimmune hepatitis 4. History or diagnosis of primary biliary cholangitis 5. History or diagnosis of primary sclerosing cholangitis 6. History or diagnosis of Wilson's disease 7. History or diagnosis of alpha-1-antitrypsin deficiency 8. History or diagnosis of hemochromatosis 9. History or diagnosis of drug-induced liver disease, as defined on the basis of typical exposure and history. 10. Known bile duct obstruction. 11. Suspected or proven liver cancer 33. History of acute or chronic pancreatitis. 34. Human immunodeficiency virus (HIV). 35. Subjects with a history of adverse reaction to heparin or heparin induced thrombocytopenia (HIT). 36. Systemic infection that the investigator judges would pose unacceptable procedural risks to the subject. 37. Known hypersensitivity to contrast media, nickel and ethanol that cannot be adequately pre-medicated. 38. Subject is depressed or on antidepressants. 39. Pregnancy or breastfeeding or plan to get pregnant in next 12 months. 40. Life expectancy of less than 5 years. 41. Unwilling or unable to comply with the follow-up study requirements. 42. Subjects or their legally authorized representatives unable to provide informed consent. 43. Concurrent medical condition that would affect the investigator's ability to evaluate the patient's condition or could compromise patient safety. 44. Currently participation in another pre-market drug or medical device clinical study.

Inclusion Criteria: * Patient's consent * Age \>18 years old * Patients with diagnosed fibromyalgia from rheumatologists * Widespread pain more than 6 months * In case of drug therapy, it should be taken at least one month before the beginning of the session and remain stable till the end of the study Exclusion Criteria: * Deep depression * Biological agent use ( TNF inhibitors) * Heamatological diseases * Systemic Infections * pregnancy * electroacupuncture contraindications (epilepsy, pacemaker/ implantable cardioverter defibrillator (ICD)

Inclusion Criteria: * Self-identify as Black/African American * Mean systolic blood pressure 120-139mmHg OR diastolic blood pressure 80-89mmHg Exclusion Criteria: 1. Mean systolic blood pressure greater than or equal to140 mm Hg, or mean diastolic blood pressure greater than or equal to 90 mm Hg 2. Currently taking antihypertensive medication 3. Self-reported history of hypertension outside of pregnancy 4. Known pregnancy 5. Self-reported history of cardiovascular disease 6. Age ≥65 years or self-reported history of chronic kidney disease, or diabetes, if systolic blood pressure ≥ 130 mm Hg or diastolic blood pressure ≥ 80 7. Planning to move out of the county within the next 18 months 8. Not having a cellular phone or landline 9. Inability to speak English

Inclusion Criteria: 1. Age:30-65 years old 2. Newly diagnosed hypertension did not use antihypertensive drugs OR Systolic blood pressure ≥140mmHg on the physical examination OR Diastolic blood pressure ≥90mmHg on the physical examination. 3. BMI≥18 kg/m2 Exclusion Criteria: 1. Receiving or have been treated with antihypertensive drugs. 2. Complications including cardiovascular and cerebrovascular diseases such as coronary heart disease and stroke. 3. Severe liver or renal insufficiency (alanine aminotransferase, aspartate aminotransferase or alkaline phosphatase is greater than 3 times the upper limit of normal OR GFR\<30ml/min/1.73m2). 4. Autoimmune diseases or thyroid diseases. 5. Women who are pregnant, nursing, or prepare to give birth during the trail. 6. Malignant disease, infectious disease, inflammatory disease and advanced liver disease. 7. Mental or intellectual abnormalities, unable to sign informed consent. 8. Complications including chronic gastrointestinal disease; or suffered from acute gastrointestinal diseases within 1 months before screening visit. 9. Received antibiotics, probiotics within 3 months before screening visit or throughout the trail. 10. Major operations were performed within six months of screening visit, or will be made during the trial. 11. Alcohol abuse (alcohol intake\>60g/d for male and alcohol intake\>40g/d for female)

Inclusion Criteria: 1\. Primary breast cancer that is: 1. Histologically confirmed invasive breast carcinoma with a primary tumor size of \> 2 cm by standard local assessment technique; 2. Breast cancer staging ( in accordance with the American Joint Commitee on Cancer(AJCC) staging system (8th edition)): early-stage (T2-3, N0-1, M0) or locally advanced (T2-3, N2 or N3, M0; T4, any N, M0); 3. HER2 positive confirmed by central laboratory, defined as immunohistochemistry (IHC) 3 +, or IHC 2+ and In Situ Hybridization (ISH) positive; 4. Hormone receptor (HR, including estrogen receptor \[ER\] and progestin receptor \[PR\]) negative by central laboratory; ER negative is defined as \< 1% nuclear staining, and PR negative is defined as \< 1% nuclear staining. 2\. Left ventricular ejection fraction (LVEF) at baseline (within 42 days prior to randomization) ≥ 55% measured by echocardiography (ECHO) or multiple gated acquisition (MUGA) scan. 3\. Adequate major organ function, meeting the following criteria: Hematology (neither blood transfusion nor correction with hematopoietic stimulating factors within 14 days prior to randomization): white blood cell count ≥ 3.0 × 109/L; absolute neutrophil count ≥ 1.5 × 109/L; hemoglobin ≥ 90 g/L; platelet count ≥ 100 × 109/L; Serum chemistry: Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 2.5 × upper limit of normal (ULN), total bilirubin ≤ 1.5 × ULN; for subjects with known Gilbert syndrome, total bilirubin ≤ 2 × ULN; alkaline phosphatase ≤ 2.5 × ULN, serum creatinine ≤ 1.5 × ULN. 4\. Women of child-bearing potential have a negative result of serum pregnancy test at screening (within 7 days prior to randomization) and not in lactation, or are infertile. Male participants and women of childbearing potential use a "highly effective" contraceptive measures until 7 months after the last dose of investigational/reference product. Exclusion Criteria: 1. Inflammatory breast cancer. 2. Stage IV (metastatic) breast cancer, bilateral breast cancer, or multicentric (multiple tumors involving more than 1 quadrant) breast cancer. 3. History of other malignancy within 5 years prior to screening (except for who have received radical treatment of carcinoma in situ of the cervix, basal cell carcinoma or squamous cell carcinoma of the skin ). 4. With serious heart disease or medical history, including but not limited to the following conditions: 1\) History of documented heart failure or systolic dysfunction with any NYHA classification(LVEF \< 50%); 2) High-risk uncontrolled arrhythmia, such as atrial tachycardia with a heart rate\> 100 bpm at rest, significant ventricular arrhythmia (e.g.,ventricular tachycardia), or higher-grade atrioventricular (AV) block (i.e.,Mobitz II second-degree AV block or third degree AV block); 3) Unstable angina pectoris, or angina pectoris requiring anti-angina medication; 4) Evidence of transmural myocardial infarction on ECG; 5) Clinically-significant valvular heart disease; 6) Poorly controlled hypertension (systolic blood pressure\> 150 mmHg and/or diastolic blood pressure\> 100 mmHg).

Inclusion Criteria: * Males and Females 21-70 years old at the time of screening. * Females of non-child bearing potential must be ≥ 1 year post-menopausal or documented as being surgically sterile. Females of child bearing potential must agree to use two methods of contraception during the entire study. * Male subjects must be willing to use clinically acceptable method of contraception during the entire study. * Have a clinical diagnosis of Type 2 Diabetes on a stable medication regimen for at least 3 months. * BMI \> 25 kg/m2). * HbA1c \< 10%). * Negative urine toxicology result at screening visit. * Able to provide written informed consent approved by an Institutional Review Board (IRB). Exclusion Criteria: * History or presence of any clinically significant illness, as detected by history, physical examination, and/or laboratory tests, that might put the participant at increased risk of adverse events (e.g., history of psychotic disorder, clinically significant mood and/or anxiety disorder, liver, or renal disease). * No prior history of myocardial infarction, stroke or heart failure. * Whole blood donation of 1 pint (500 mL) within 8 weeks prior to Screening. Donations of plasma, packed RBCs, platelets or quantities less than 500 mL are allowed at investigator discretion. * Hemoglobin \< 9g/dL. * Liver enzymes ≥ 2 times upper normal limit and/or clinical signs/symptoms consistent with liver disease, including but not limited to nausea, vomiting, jaundice, itching, abdominal pain, or edema. * History of clinically significant adverse events associated with cannabis intoxication (e.g., severe anxiety and panic, paranoia and psychosis, sustained tachycardia, or severe hypotension). * History of seizures, head trauma, or other history of CNS insult that could predispose the participant to seizures. * Use of any THC containing products within 30 days prior to the screening visit. * Current use of tobacco products. * Individuals who are pregnant or lactating/breastfeeding. * Current use of insulin to treat Type 2 Diabetes. * Unable or unwilling to follow the study protocol or who are non-compliant with screening appointments or study visits. * Any other condition(s) that might reduce the chance of obtaining study data, or that might cause safety concerns, or that might compromise the ability to give truly informed consent.

Inclusion Criteria : * Patients who have received antihypertensive treatment with two antihypertensive drugs (ARB/ACE inhibitor and Ca channel antagonist, either as a single agent or as a combination) for at least 4 weeks prior to obtaining consent, with no change in the type or dosage. * Patients with a mean seated office blood pressure of between 140 mmHg and 180 mmHg systolic and between 90 mmHg and 110 mmHg diastolic at screening visit. * Patients with a mean 24-hour ABPM (ambulatory blood pressure measurement) of between 130 mmHg and 170 mmHg systolic and between 80 mmHg and 105 mmHg diastolic at baseline visit Exclusion Criteria * Lacks appropriate renal artery anatomy for renal denervation * Secondary hypertension other than sleep apnea * Type 1 diabetes mellitus or uncontrolled Type 2 diabetes * Any history of cerebrovascular event or severe cardiovascular event, within 6 months prior to consent * Repeated hospitalization for hypertensive crisis (twice or more) within 12 months prior to obtaining consent, or any hospitalization for hypertensive crisis within 3 months prior to obtaining consent * Patients prescribed to drugs that have antihypertensive effects for other chronic diseases, and the investigator considers that discontinuation of these drugs may pose a serious risk to health * Patients who are taking drugs known to affect blood pressure and the investigator judges that it is not possible to discontinue these drugs during the study period * Patients with a history of persistent or permanent atrial tachyarrhythmia * Patients with active implantable medical devices * Primary pulmonary hypertension * Patients with contraindications or unacceptable anaphylactic reactions or uncontrolled allergy to contrast media * Night shift workers * Pregnant, nursing or planning to become pregnant * Patients with any of the following central laboratory tests at screening * Plasma aldosterone/renin ratio greater than or equal to 200 and plasma aldosterone greater than or equal to 60 pg/ml * HbA1c greater than or equal to 8.0% * eGFR less than 40 mL/min/1.73m2

Inclusion Criteria * The age is more than 18 years old; * Pathology confirmed malignant breast tumor; * No clinical diagnosis of other malignancies, unstable complications or uncontrolled infection; * Life expectancy is greater than 6 month; * The main organ function is normal; * The subjects volunteered to participate in this study, signed informed consent, followed up with good compliance. Exclusion Criteria * Patients who had suffered from other malignant tumors; * With uncontrolled bacterial, viral or fungal infections; * With physical or mental disorders * Without or limited civil capacity; * Infected with human immunodeficiency virus (HIV)； * Circumstances in which the investigator considers it inappropriate to participate in this study.

Inclusion Criteria: * Being female. * Ages 30-64. * Being an Ohio State University (OSU) patient who uses MyChart. * Undergoing routine screening mammography. * Normal BI-RADS1. * At elevated breast cancer risk by the Cancer Risk Assessment (CRA) tool. * Able to read and speak English. * Provide consent. Exclusion Criteria: * Previous genetic counseling. * Previous genetic testing for cancer risk or known mutation in a breast cancer gene: ATM, BARD1, BRCA1, BRCA2, CDH1, CHEK2, NBN, PALB2, PTEN, TP53. * Previous diagnosis of breast or ovarian cancer or personal history of lobular carcinoma in situ (LCIS) or breast hyperplasia (with or without atypia). * Being a member of a focus group that assisted with the development of the intervention.

Inclusion Criteria: MDD Patients: * willing and able to give written informed consent * men or women, 18-65 years of age * primary diagnosis of DSM-V MDD, current, as diagnosed by the SCID-I * score of ≥20 on the Beck Depression Inventory, which will include patients characterized as having "moderate/severe" (20-28) or "very-severe" (29-63) depressive symptoms * off all antidepressant therapy for at least 8 weeks prior to the baseline visit Healthy Controls: * willing and able to give written informed consent * men or women, 18-65 years of age Exclusion Criteria: MDD Patients: * history of any bipolar disorder or psychotic disorder * active psychotic symptoms of any type * substance abuse/dependence within 6 months of study entry (as determined by SCID) * unstable cardiovascular, endocrinologic, hematologic, hepatic, renal, or neurologic disease (as determined by physical examination and laboratory testing), including upper respiratory disease or asthma, glaucoma or porphyria. * active suicidal ideation as determined by a score ≥3 on the Columbia Suicide Severity Rating Scale (C-SSR) * use of any recreational drugs as confirmed by urine drug screen at the time of scanning * pregnancy or lactation * use of glucocorticoids at any time during the study * Raynaud's disease that may interfere with the cold-pressor * contraindications for MRI * MMSE score \<28 * elevated blood pressure prior to infusion (systolic \> 160 or diastolic \>100) * history of treatment resistance as determined by ATRQ * prior adverse reaction to ketamine * use of antipsychotic medications * use of greater than 2mg daily of lorazepam or similar benzodiazipine. * Regular smoker as self-reported Healthy Controls: * evidence of any psychiatric disorder with exception of specific phobia, and no history of any psychiatric disorder except mild past substance use disorder as diagnosed by the SCID-I * history of any substance abuse within the last 6 months * use of any recreational drugs as confirmed by urine drug screen at the time of scanning * pregnancy or lactation * use of glucocorticoids at any time during the study * Raynaud's disease that may interfere with the cold-pressor * contraindications for MRI * MMSE score \<28 * Regular smoker as self-reported

Inclusion Criteria: * Subjects aged ≥ 45 years * Have given their consent to participate in the study * Subjects who have a smartphone Exclusion Criteria: * Current or previous cardiovascular disease (personal history of myocardial infarction, angina pectoris, arterial revascularization procedures, stroke, TIA, peripheral artery disease) * Psychiatric disorders * Participation in other clinical trials

Inclusion Criteria: * A clinical, radiological or histologic diagnosis of cirrhosis of any etiology * Splenomegaly with secondary hypersplenism * gastroesophageal variceal bleeding * Informed consent to participate in the study Exclusion Criteria: * Hepatocellular carcinoma or any other malignancy, * Child-Pugh grade C * Recent peptic ulcer disease * History of Hemorrhagic stroke * Pregnancy. * Uncontrolled Hypertension * Human immunodeficiency virus (HIV) infection

Inclusion Criteria: * All sexes and genders * All ethnicities * Ages 14-21 * Postpubertal (Tanner stage \> 3) * No medications that will interfere with the study (including antidepressants, mood stabilizers, hormone supplements, steroids, etc.) for at least 2-6 weeks (depending on exact medication) * Currently being seen by a clinician who will treat the participant with fluoxetine or escitalopram * The ability to provide assent, understand, and complete all study procedures * Caregiver consent (if applicable) Exclusion Criteria: * Primary mental health diagnosis other than a depressive disorder according to DSM-V * Any contraindications to MRI scanning, phlebotomy, or SSRI treatment * Stimulant usage * A concussion within the last 6 weeks or any lifetime concussion with loss of consciousness for at least 10 minutes * Any inflammatory conditions or use of anti-inflammatory medications that may influence study findings * Any major neurological or developmental disorders which could impact the participant's ability to comply with study procedure * Meeting for current or lifetime criteria of mania or psychosis, diagnosis of bipolar disorder, or any substance use disorders * First-degree relative with current, past, or suspected mania or psychosis

Inclusion Criteria: * WHO performance scale ≤2. * Females at least 50 years of age with unifocal cT1N0 breast cancer on mammography, ultrasound and MRI. * Patients with an indication for chemotherapy or HER2-targeted therapy according to Dutch National Oncoline Guidelines or own hospital protocols are not eligible. Patients with an indication for endocrine therapy are eligible. * Tumor size as assessed on MRI. * On tumor biopsy: * Bloom-Richardson grade 1 or 2. * Non-lobular invasive histological type carcinoma. * LCIS or (non-extensive) DCIS is accepted. * ER positive tumor receptor. * HER2 negative tumor. * Tumor-negative sentinel node (excluding isolated tumor cells). * Adequate communication and understanding skills of the Dutch language. Exclusion Criteria: * Legal incapacity. * BRCA1, BRCA2 or CHEK2 gene mutation. * Distant metastasis. * Previous history of breast cancer or DCIS. * Other type of malignancy within 5 years before breast cancer diagnosis. Patients with adequately treated malignancy longer than 5 years before breast cancer diagnosis are eligible for inclusion. * For adequately treated carcinoma in situ of the cervix or basal cell carcinoma of the skin no specific time span to breast cancer diagnosis is required for inclusion. * Collagen synthesis disease. * Signs of extensive DCIS component on histological biopsy or on imaging (e.g. no extensive calcifications on mammography). * Invasive lobular carcinoma. * MRI absolute contraindications as defined by the Department of Radiology. * Nodal involvement with cytological or histological confirmation. * Indication for treatment with (neo-)adjuvant chemotherapy. * Non-feasible dosimetric RT plan.

Inclusion: In order to be eligible to participate in this study, an individual must meet all of the following criteria: 1. Detroit-area resident (defined as those who attended a Detroit-area community event) 2. ≥18 years of age 3. At least one of the following: A) Screening systolic BP ≥ 140 and/or diastolic BP ≥ 90 mm Hg OR B) Screening BP 130-139 mm Hg plus ≥1 additional HF risk factors: i. Diabetes (HbA1c ≥ 6.5%) ii. CKD stage 3(i.e. eGFR 30-60 mL/min/m2) OR C) Treated (1-2 antihypertensive medications) stage 1 HTN (systolic BP 130-139 and/or diastolic BP 80-89) with or without \>1 additional HF risk factors OR D) Treated stage 1 HTN w/ systolic BP 120-129 with additional HF risk factors: i. Diabetes (HbA1c ≥ 6.5%) ii. CKD stage 3(i.e. eGFR 30-60 mL/min/m2) Exclusion Criteria: An individual who meets any of the following criteria will be excluded from participation in this study: 1. Previous diagnosis of HF 2. Uncontrolled diabetes (HbA1C ≥8.0% from SOC screening labs) 3. Chronic use of insulin or \>1 anti-diabetic medication 4. Self-reported pregnancy (or planning to become pregnant in the next year) 5. Severely uncontrolled BP at screening visits (SBP ≥180 mm Hg and/or diastolic BP ≥110 mmHg) 6. Point of care (POC) BNP measurement ≥400 ng/L. If POC BNP was not obtained, then NTproBNP ≥ 1000 ng/L from screening labs will be excluded. 7. eGFR \<45 ml/min/sq-m on SOC screening labs

Inclusion Criteria: * Subjects aged ≥18 years (inclusive). * Histologically confirmed, perioperative invasive breast cancer that is resectable without metastasis(stage I-III). * No anti-breast cancer systematic therapy received, and planning to receive surgery and systemic therapy. * Eastern Cooperative Oncology Group (ECOG) performance status of 0-2. * With Adequate Organ Function: a. Bone marrow function: Hemoglobin ≥ 10 g/dL; Absolute leucocyte count ≥ 4×10\^9/L; Absolute neutrophil count ≥ 1.5×10\^9/L; Platelets ≥ 100 × 10\^9/L; b. Liver function (based on the normal values specified by study site): Serum total bilirubin ≤ 1.5 × the upper limit of normal (ULN); Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 × ULN; c. Renal function (based on the normal values specified by study site): Serum creatinine ≤ 1.5 × ULN. * The patients voluntarily signed an informed consent form. Exclusion Criteria: * Known to have other aggressive malignant tumor that is progressing or requires systemic treatment in the past 5 years (does not exclude subjects with skin basal cell carcinoma, skin squamous cell carcinoma, breast ductal carcinoma in situ or cervical cancer in situ that has received curative treatment). * Have a clear history of neurological or mental disorders, including epilepsy or dementia, etc.; have a history of psychotropic drug abuse or drug abuse. * Known history of allergy to the drug components in MRD strategy; history of immunodeficiency, or history of organ transplantation. * There are other concomitant diseases that seriously threaten the patient's safety or affect the patient's completion of the study, such as serious infection, liver disease, cardiovascular disease, kidney disease, respiratory disease or uncontrolled diabetes or dyslipidemia. * Female patients during pregnancy or lactation. * The investigator determines that subjects are not appropriate to participate in the study due to other factors.

Inclusion Criteria: * Enrolled in any Institutional Review Board (IRB) protocol of the Pre-Vent Study that had signed consent, or in any IRB protocol of the Pre-Vent Study that authorized re-contact for future research * Born \<29 weeks gestational age * Age at enrollment less than 7 years old Exclusion Criteria: * Subject was withdrawn from the Pre-Vent study after signing Pre-Vent consent form, for any reason * Subject had no physiological data recorded as part of Pre-Vent * Lack of regulatory approval from local IRB or Department of Children and Family Services (DCFS) to recontact subjects * Adopted by non-consenting family * Parent refused further contact, prior to approach for Post-Vent * Infant enrolled in Pre-Vent at Washington University St Louis, which is not a Post-Vent participating site.

Inclusion Criteria: * Patients with BMI 35-40 kg/m2 with associated medical problems (Diabetes Mellitus, Hipertension, Dyslipidemia, Obstructive Sleep Apnea Syndrome) or 40-50 kg/m2 with or without associated medical problems, who comply with the regulatory rules for bariatric surgery in Spain (SECO and AEC) Exclusion Criteria: * General contraindications to kind of surgery * BMI \> 50 kg/m2 * Known drug or alcohol abuse * ASA (American Society of Anesthesiology) physical status classification \> III * Inability to follow the procedures of the study

Inclusion Criteria: 1. Participants must sign the informed consent form voluntarily and follow the plan requirements. 2. No gender limit. 3. Age: ≥18 years old and ≤75 years old (phase Ia); ≥18 years old (phase Ib). 4. Expected survival time ≥ 3 months. 5. Locally advanced or metastatic gastrointestinal tumor and other solid tumor confirmed by histopathology and/or cytology, which are incurable or currently without standard treatment. 6. Participants must agree to provide archived tumor tissue specimens or fresh tissue samples of the primary tumor or metastasis; if the participant is unable to provide tumor tissue samples, the investigator will evaluate whether the participant could be enrolled if other criteria are fit to join the group. 7. Participants must have at least one assessable lesion in phase Ia; participants must have at least one measurable lesion that meets the definition of RECIST v1.1 in phase Ib. 8. Has an Eastern Cooperative Oncology Group performance status (ECOG PS) 0-1 9. Toxicity of previous antitumor therapy has returned to ≤ level 1 as defined by NCI-CTCAE v5.0 (except for asymptomatic laboratory abnormalities considered by the investigators, such as elevated ALP, hyperuricemia, and elevated blood glucose; Toxicities with no safety risk were excluded, such as alopecia, hyperpigmentation, and grade 2 peripheral neurotoxicity. Or except decreased hemoglobin but ≥90 g/L). 10. Has adequate organ function before registration, defined as: a) Bone marrow function: Absolute neutrophil count (ANC) ≥1.5×109/L, Platelet count ≥100×109/L, Hemoglobin ≥90 g/L; B) Hepatic function: Total bilirubin (TBIL≤1.5 ULN), AST and ALT ≤2.5 ULN for participants without liver metastasis, AST and ALT ≤5.0 ULN for liver metastases; c) Renal function: Creatinine (Cr) ≤1.5 ULN, or creatinine clearance (Ccr) ≥50 mL/min (according to the Cockcroft and Gault formula). 11. Coagulation function: International normalized ratio (INR)≤1.5×ULN, and activated partial thromboplastin time (APTT)≤1.5ULN. 12. Urinary protein ≤2+ or ≤1000mg/24h. 13. For premenopausal women with childbearing potential, a pregnancy test must be taken within 7 days prior to the start of treatment. Serum or urine pregnancy must be negative and must be non-lactating. Adequate barrier contraceptive measures should be taken during the treatment and 6 months after the end of treatment for all participants (regardless of male or female). Exclusion Criteria: Patients screened for any of the following conditions will not be included in this study: 1. Antitumor therapy such as chemotherapy, biotherapy, immunotherapy, radical radiotherapy, major surgery (as defined by the investigators), and targeted therapy (including small-molecule tyrosine kinase inhibitors) within 4 weeks prior to initial administration or within 5 half-lives, whichever is shorter; Mitomycin and nitrosourea were administered within 6 weeks before the first administration; Oral fluorouracil drugs such as Tizio, capecitabine, or palliative radiotherapy within 2 weeks before first administration; Traditional Chinese medicines with anti-tumor indications were administered within 2 weeks before the first dose. 2. Prior treatment with ADC drugs targeting TROP2 or ADC drugs using camptothecin derivatives (topoisomerase I inhibitors) as toxins. 3. Participants with history of severe heart disease, such as: symptomatic congestive heart failure (CHF) ≥ grade 2 (CTCAE 5.0), New York Heart Association (NYHA) ≥ grade 2 heart failure, history of transmural myocardial infarction, unstable angina pectoris etc. 4. Participants with prolonged QT interval (male QTc\> 450 msec or female QTc\> 470 msec), complete left bundle branch block, III grade atrioventricular block. 5. Active autoimmune diseases and inflammatory diseases, such as: systemic lupus erythematosus, psoriasis requiring systemic treatment, rheumatoid arthritis, inflammatory bowel disease and Hashimoto's thyroiditis, etc., except for type I diabetes, hypothyroidism that can be controlled only by alternative treatment, and skin diseases that do not require systemic treatment (such as vitiligo, psoriasis). 6. The presence of a second primary tumor within 5 years prior to initial administration, except for radical basal cell carcinoma of the skin, squamous cell carcinoma of the skin, and/or radical resected carcinoma in situ. 7. Screening for unstable thrombotic events such as deep vein thrombosis, arterial thrombosis and pulmonary embolism requiring therapeutic intervention within the first 6 months; Infusion device-related thrombosis is excluded; 8. Patients with poorly controlled pleural effusion with clinical symptoms were judged by researchers to be unsuitable for inclusion. 9. Participants with poorly controlled hypertension by antihypertensive drugs (systolic blood pressure\>150 mmHg or diastolic blood pressure\>100 mmHg). 10. Lung disease defined as grade ≥3 according to CTCAE V5.0; ≥2 grade of radioactive lung disease, current or history of interstitial lung disease (ILD). 11. There are symptoms of active central nervous system metastasis. However, the researchers concluded that patients with stable brain parenchymal metastases could be included. Stable is defined as: a. The seizureless state persists for \> 12 weeks with or without antiepileptic medication; b. Glucocorticoid use is not required; c. Two consecutive MRI scans (at least 4 weeks between scans) showed stable imaging status; d. Asymptomatic patients stable for more than 1 month after treatment. 12. Participants who have a history of allergies to recombinant humanized antibodies or human-mouse chimeric antibodies or any of the components of BL-M02D1. 13. Participants have a history of organ transplantation or allogeneic stem cell transplantation (Allo-HSCT). 14. In the adjuvant (or neoadjuvant) treatment of anthracyclines, the cumulative dose of anthracyclines is\> 360 mg/m2. 15. Human immunodeficiency virus antibody (HIVAb) positive, active tuberculosis, active hepatitis B virus infection (HBV-DNA copy number\> the lower limit of detection) or active hepatitis C virus infection (HCV antibody positive and HCV-RNA \> the lower limit of detection). 16. Participants with active infections requiring systemic treatment, such as severe pneumonia, bacteremia, sepsis, etc. 17. Participated in another clinical trial within 4 weeks prior to participating in the study. 18. Pregnant or nursing women. 19. Other conditions that the investigator believes that it is not suitable for participating in this clinical trial.

Inclusion Criteria: * Prescribed 1 or 2 blood pressure medications and a statin medication for \> 1 year * Has supply of medications at the time of enrollment * Medication possession ratio 40-80% for at least one of those medications for the past 6 months * Systolic blood pressure \> 140 mm Hg at most recent check * Owns a smartphone or tablet operating the iOS or Android operating system Exclusion Criteria: * Unable or unwilling to provide informed consent, including but not limited to cognitive or language barriers (reading or comprehension of English) * Systolic blood pressure \> 180 mm Hg at their last bp check * Anticipated life expectancy less than 6 months * Any other reason why it is not feasible to complete the entire study