Recruiting
Acoustic Waveform Respiratory Evaluation
The study will evaluate the feasibility of using smartphone speakers and microphones to evaluate the caliber of the airways, detect airway obstruction, aid in airway disease diagnosis, and identify disease exacerbations.
ClinicalTrials.gov IDNCT06512064
PhaseNA
Enrollment800
SponsorIndiana University
Age8 Years
SexALL
Conditions studied
Asthma, COPD, Cystic Fibrosis, Ciliary Motility Disorders, Bronchiectasis, Airway Malacia, Healthy Control
About this study
The study will evaluate the feasibility of using smartphone speakers and microphones to evaluate the caliber of the airways, detect airway obstruction, aid in airway disease diagnosis, and identify disease exacerbations.
Interventions
- Diagnostic Test: AWARE — AWARE testing to estimate lung function and aid in disease diagnosis
Primary outcomes
- Accurate and reliable disease diagnosis (Up to two weeks per subject)
- Estimation of FEV1 (Up to two weeks per subject)
- Estimation of FVC (Up to two weeks per subject)
- Estimation of FEV1/FVC (Up to two weeks per subject)
- Estimation of FEF2575 (Up to two weeks per subject)
- Estimation of R5 (Up to two weeks per subject)
- Estimation of R20 (Up to two weeks per subject)
- Estimation of R5-R20 (Up to two weeks per subject)
Eligibility information
Inclusion Criteria:
1. Age 8-70 years
2. Ability to perform spirometry and oscillometry
3. Signed informed consent (and assent for children as appropriate)
4. No respiratory or other major disease (for healthy controls), or physician-diagnosed asthma, COPD, CF, or other airway diseases
Exclusion Criteria:
1. Inability or unwillingness to perform AWARE, spirometry, or oscillometry
2. Acute or chronic illness that, at the judgement of investigators, may affect lung function and alter the results of AWARE or the reference PFTs (spirometry and AOS)
Study locations
- Indiana University, Indianapolis, Indiana 46202 United States
- University of Pittsburgh, Pittsburgh, Pennsylvania 15224 United States
Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-30.