Mitigating Chronic Respiratory Disease Through the Lens of Multi-Morbidity

Conditions studied

Chronic Obstructive Pulmonary Disease (COPD), Asthma, Preserved Ratio Impaired Spirometry

About this study

The investigators aim to make it easier to find people with undiagnosed long-term lung health problems (such as asthma, and chronic obstructive pulmonary disease, COPD, collectively called 'Chronic Respiratory Diseases', CRDs) living in Brasil. Because people with undiagnosed CRDs often have other medical problems too, such as heart problems, high blood pressure and diabetes (collectively called 'Long Term Conditions', LTC), the investigators will look for undiagnosed CRD in people with LTC when they are attending appointments at local health centres in the cities of Sao Carlos and Sao Paulo. To look for undiagnosed CRDs the investigators will use two questionnaire-based methods called 'COLA' and 'SBQ'. These are quick and simple to do. All participants will also have tests of their lung function completed including spirometry and Fractional Exhaled Nitric Oxide so that the investigators can make a definite diagnosis of CRDs. When the study is complete, the investigators will examine how well the COLA and SBQ questionnaires perform in identifying people with a definite diagnosis of CRD. In total, the investigators aim to recruit 859 people.

Primary outcomes

• Discriminative accuracy of the 'COLA' case-finding questionnaire for diagnosis of abnormal spirometry (Baseline: all assessments are conducted at one visit and the discriminative accuracy of the 'COLA' case-finding questionnaire for diagnosis of abnormal spirometry will use the COLA and spirometry data from the single visit.)

Eligibility information

Study locations

• Multiple primary care sites, São Carlos, São Paulo Brazil
• Multiple primary care sites, São Paulo, São Paulo Brazil