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Inclusion Criteria: 1. Age between 18 and 80 years. 2. Patients scheduled for non-cardiac surgery under general anesthesia. 3. Patients who have a scheduled standard preoperative electrocardiogram (ECG). 4. Patients capable of understanding the study and willing to provide medical records for research purposes, and who have signed the informed consent form. Exclusion Criteria: 1. Patients scheduled for emergency surgery. 2. Patients who explicitly refuse to participate or withdraw consent. 3. Patients with specific comorbidities that interfere with ECG interpretation or data collection (e.g., implanted pacemakers).

Inclusion Criteria: 1. Age ≥18 years (or legal age of consent in the study jurisdiction). 2. Able to provide written informed consent and willing/able to comply with study procedures, visits, and follow-up. 3. Advanced solid tumor malignancy (excluding lymphoma and other hematologic malignancies), with disease that has progressed on, is intolerant of, or is ineligible for standard therapies known to provide clinical benefit, or for whom no standard therapy is available. 4. ECOG performance status 0-1. 5. Measurable disease per IT-RECIST (Parts A1/A2) and RECIST v1.1 (Part A3), as applicable. 6. At least one injectable tumor lesion, meeting superficial or visceral criteria and deemed safe/accessible for injection: 1. Superficial lesions: ≥10 mm in longest diameter (or multiple lesions each ≥5 mm with aggregate longest diameter ≥10 mm), and ≤80 mm, accessible for direct injection (± ultrasound guidance). 2. Visceral lesions: ≥10 mm and ≤50 mm in longest diameter, accessible for direct injection. 3. Injected lesions must not involve/encase major blood vessels or otherwise pose an unacceptable bleeding/vascular risk, per investigator assessment and imaging review (as applicable). 4. Expansion (Part A3): at least 1 measurable lesion and at least 1 additional injectable lesion suitable for injection. 7. Adequate recovery from prior therapy: toxicities from prior anticancer treatment resolved to Grade ≤1 or baseline (except alopecia, controlled endocrine toxicities, or other stable toxicities as allowed per protocol/sponsor). 8. Adequate organ function, including hepatic, renal, and coagulation parameters per protocol-defined thresholds. 9. Adequate bone marrow function without transfusion support within 7 days prior to enrollment, per protocol-defined thresholds. 10. Tumor tissue requirements: willingness to provide a pre-treatment tumor biopsy and on-study post-treatment biopsy, if an accessible lesion is available and safe for biopsy, and biopsy does not interfere with injection/response assessment; and/or availability of archival tumor tissue (obtained within 2 years prior to treatment), per protocol. 11. Contraception requirements: participants of reproductive potential agree to use effective contraception and avoid pregnancy/fathering children from screening through 30 days after last dose; women of childbearing potential must have a negative pregnancy test within 14 days prior to first dose, per protocol. Exclusion Criteria: 1. Serious psychiatric, medical, or other condition that would interfere with study participation or protocol procedures, in the investigator's judgment. 2. History of solid organ transplant. 3. Alpha-1 antitrypsin deficiency. 4. Hereditary or acquired bleeding disorder/coagulation factor deficiency. 5. Active autoimmune disease requiring systemic treatment within the past 6 months, except clinically stable autoimmune conditions in remission not requiring systemic therapy (per protocol). 6. Baseline QTcF \>480 ms. 7. Pregnant or breastfeeding. 8. Prior severe immune-mediated adverse event (imAE) from immunotherapy: ≥Grade 3 imAE within the past 16 weeks, any Grade 4 life-threatening imAE, or any neurologic/ocular AE of any grade (except controlled endocrine AEs on stable replacement therapy per protocol). 9. Another active malignancy (current or within the past 2 years) other than the disease under study, except specified low-risk cancers treated with curative intent or under active surveillance (per protocol). 10. Recent anticancer therapy: receipt of systemic anticancer therapy (including investigational agents) within 2 weeks prior to first dose (or 4 weeks for monoclonal antibodies/ADCs/other long half-life biologics), or within 5 half-lives, whichever is shorter. 11. Recent radiotherapy within 2 weeks prior to first dose. 12. Unresolved toxicity from prior anticancer therapy to \>Grade 1 or not at baseline (except Grade ≤2 neuropathy and other allowed exceptions per protocol). 13. Uncontrolled or unstable brain metastases (eligible only if neurologically stable for ≥4 weeks, and off steroids or on stable/decreasing steroids ≤10 mg/day prednisone equivalent; carcinomatous meningitis excluded). 14. Active infection requiring systemic antibacterial, antifungal, or antiviral therapy within 14 days prior to first dose. 15. Chronic viral infections not meeting protocol criteria: 1. HBV with detectable DNA unless on appropriate antiviral therapy 2. Active HCV with detectable HCV RNA (treated HCV permitted if RNA undetectable) 3. HIV infection with CD4+ count \<300/μL, detectable viral load, or HIV-related illness within 6 months 16. Use of systemic anticoagulants (e.g., warfarin, LMWH, DOACs) within 14 days prior to first dose. 17. Chronic systemic corticosteroids \>10 mg/day prednisone equivalent, or systemic immunosuppressive/anti-inflammatory medications within 4 weeks prior to first dose, except permitted topical/inhaled/local formulations or short courses for premedication per protocol. 18. Known allergy/hypersensitivity to N17350 or any excipients.

Inclusion Criteria: * Overweight/obese (BMI: 30-45 kg/m²) who have had T2D for less than 6 years or longer than 10 years, and are on treatment with diet alone or diet plus oral medication. * Overweight/obese (BMI: 30-45 kg/m²) who are at pre-diabetes stage, defined as fasting blood glucose 5.6-6.9 mmol/L. * Overweight/obese (BMI: 30-45 kg/m²) who are non-diabetic (control group). * Age between 45 and 79 years inclusive. * Post-menopausal women only (to exclude sex hormone effects on lipid metabolism). * Good communication in English (able to give informed consent and follow dietary advice). * Willing and able to adhere to the study protocol, including dietary intervention and scheduled follow-up visits. Exclusion Criteria: * Insulin therapy * HbA1c \>12% (108 mmol/mol) * Weight loss \>5 kg in last 6 months * Recent MI (within 6 months) * Known cancer in last 5 years * First-degree relatives of people with T2D (control group) * History of gestational diabetes * MRI contraindications (metal implants, claustrophobia) * Alcohol \>14 units/week * Advanced kidney or liver disease * Use of steroids or antipsychotics * Participation in another clinical trial * Life expectancy \<1 year * Allergy to local anaesthetic (for biopsy subgroup) * Any disorder that may jeopardise safety or compliance

Inclusion Criteria: 1. Individuals aged 18 years or older. 2. Individuals with type 2 diabetes. 3. Individuals with type 2 diabetes not reaching HbA1c target of under 7.0% Exclusion Criteria: 1. Individuals with type 1 diabetes, gestational diabetes, or other forms of diabetes that are not type 2 diabetes. 2. Pregnant individuals. 3. Individuals at their HbA1c target (HbA1c under 7.0%) or those with a limited life expectancy, frailty, or lack hypoglycemic awareness (i.e., those with an A1c target above 7.0%) . 4. Individuals unable to provide consent or who are unwilling to attend follow-up visits.

Inclusion Criteria: * Gender is not limited. Applicants must be 18 years old or above; * Study patients whose eyes were diagnosed with open-angle glaucoma; * The study eye was diagnosed with cataract and met the conditions for phacoemulsification, with the best corrected visual acuity ≤0.7(patients with the best corrected visual acuity \>0.7 who were determined by the researcher to need cataract surgery could be enrolled); * Angular endoscopy confirmed that the opening Angle of the study eye was normal (defined as Shaffer grade ≥3, and there was no peripheral anterior iris adhesion, polycythemia or other abnormal conditions that might affect the correct placement of the stent); * The patient is capable and willing to provide written informed consent and participate in the regular postoperative follow-up as required. Exclusion Criteria: * Patients with angle-closure, pigmentary or pseudo-exfoliative glaucoma; * Patients with traumatic, malignant uveitis, neovascular or glaucoma related to vascular diseases; * Suffering from severe diabetic retinopathy, retinal detachment, central retinal vein or artery occlusion, retinal chromosomal degeneration, macular degeneration, macular edema, and determined by researchers to potentially affect surgical safety; * Patients with identifiable congenital abnormalities of the anterior chamber Angle; * Having clinically significant corneal dystrophy, active inflammation or having undergone surgery that may interfere with the reliability of intraocular pressure measurement; * Patients with retrobulbar tumors, thyroid eye disease, cavernous sinus fistula, Sturge-Weber syndrome or any other disease that may cause elevated venous pressure in the outer sclera; * Suffering from eye or systemic diseases that affect surgical safety or subsequent examinations; * Pregnant women, lactating women, women of childbearing age who plan to get pregnant during the research period or are unable to take effective contraceptive measures; * Failure to follow the doctor's advice; * Other circumstances where the researcher determines that the patient is not suitable for inclusion

Inclusion Criteria: 1. Aged 18-80 years. 2. Diagnosis of liver cirrhosis based on clinical, laboratory, and imaging examinations. 3. Complicated with gastrointestinal bleeding caused by esophagogastric varices. 4. Patients with hypersplenism and thrombocytopenia (platelet count \< 100 × 10\^9/L). Exclusion Criteria: 1. Patients who have previously undergone splenectomy, PSE, transjugular intrahepatic portosystemic shunt (TIPS), varicocelectomy, sclerotherapy, or balloon-occluded retrograde transvenous obliteration. 2. Hepatocellular carcinoma or other malignant tumors. 3. Patients with hepatic encephalopathy who are unable to cooperate, or those with liver failure or a Child-Pugh score \>13. 4. Patients with allergies to intravenous anesthetics. 5. Patients with unstable vital signs, associated organ dysfunction, active infection, or cardiopulmonary insufficiency, who cannot tolerate endoscopy. 6. Patients who are unable or unwilling to provide informed consent. 7. Uncorrectable coagulation disorders (INR \>1.5 and/or fibrinogen \<120 mg/dL) or uncorrectable thrombocytopenia (platelet count \<20 × 10\^9/L). 8. Patients who have used beta-blockers within the past 24 hours

Inclusion Criteria: * Adults aged 19 years and older * Participants diagnosed with POAG or OH * Have fully explained and understood the study and have voluntarily given written informed consent. Exclusion Criteria: * Acute or chronic angle-closure glaucoma * Congenital glaucoma, secondary glaucoma (open-angle glaucoma)

Inclusion Criteria: * Participants must be diagnosed with endocrine-resistant, PIK3CA-mutated, HR+/HER2- LA/mBC, following recurrence on or after completing adjuvant endocrine therapy * Participants must receive the treatment of inavolisib for the first time * PIK3CA mutation status should be detected by a National Medical Products Administration (NMPA)-approved or validated assay \[Polymerase Chain Reaction (PCR) or Next Generation Sequencing (NGS)\] by testing of blood or tumor tissue prior to the initiation of inavolisib Exclusion Criteria: * Participants for which the treatment with inavolisib is not indicated per prescribing information. If the participant starts palbociclib and fulvestrant first, and starts inavolisib after getting a PIK3CA mutation-positive test result later, the palbociclib and fulvestrant will not be deemed as a different line of therapy. However, the medical order of PIK3CA mutation test must be made before or at the same time with the prescription of palbociclib and fulvestrant * Participants not receiving treatment for LA/mBC with inavolisib according to standard of care (SOC) and in line with the current summary of product characteristics (SPC)/local labeling * At the investigator's discretion, any reason that makes the participant hard to follow up or unsuitable to participate in the study

Inclusion Criteria: * Male or female participants aged 18 to 75 years. * Histologically or clinically diagnosed Hepatocellular Carcinoma (HCC) according to AASLD or EASL guidelines. * Disease stage classified as Barcelona Clinic Liver Cancer (BCLC) stage B (unresectable) or stage C. * No prior systemic treatment for advanced HCC (treatment-naïve). * At least one measurable lesion according to RECIST v1.1 criteria. * Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. * Child-Pugh liver function class A (score 5-6). * Life expectancy of at least 3 months. * Adequate bone marrow function: Absolute neutrophil count (ANC) ≥ 1.5 × 10\^9/L, Platelets ≥ 75 × 10\^9/L, and Hemoglobin ≥ 90 g/L. * Adequate liver function: Total bilirubin ≤ 1.5 × ULN; ALT and AST ≤ 5 × ULN. * Adequate renal function: Serum creatinine ≤ 1.5 × ULN or creatinine clearance ≥ 50 mL/min. * Adequate coagulation function: INR ≤ 1.5 or PT ≤ 1.5 × ULN. * Participants suitable for hepatic artery catheterization and HAIC treatment as assessed by the investigator. * Willingness to provide written informed consent. Exclusion Criteria: * Known hypersensitivity or allergy to Oxaliplatin, Fluorouracil, Leucovorin, Donafenib, Pucotenlimab, or any of their excipients. * Previous treatment with anti-PD-1/PD-L1 antibodies, anti-CTLA-4 antibodies, or other immunomodulatory agents. * Diagnosis of other malignant tumors within the past 5 years (excluding cured basal cell carcinoma of the skin or carcinoma in situ of the cervix). * Presence of central nervous system (CNS) metastases. * Active, known, or suspected autoimmune disease (e.g., systemic lupus erythematosus, rheumatoid arthritis) requiring systemic treatment. * History of gastrointestinal bleeding, esophageal or gastric varices with bleeding risk, or other active bleeding within 6 months prior to enrollment. * Severe cardiovascular disease, including unstable angina, myocardial infarction within 6 months, or uncontrolled hypertension. * Active infection requiring systemic antibiotic therapy. * Hepatitis B virus (HBV) DNA \> 2000 IU/mL (participants must receive antiviral treatment to suppress viral load). * Known Human Immunodeficiency Virus (HIV) infection or active Syphilis infection. * Anatomy unsuitable for hepatic arterial catheterization (e.g., severe vascular variation or occlusion). * Pregnant or breastfeeding women. * Any condition that, in the opinion of the investigator, would jeopardize the safety of the participant or the integrity of the study data.

Inclusion Criteria (Parents of children with disabilities): 1. Community-dwelling adults (aged ≥18 years) with primary caregiving responsibility for a child with disabilities (aged \<18 years) who is enrolled in a participating clinic; 2. Expected to use services at the participating clinic at least once per week over the next three months; 3. Willing to learn strategies to cope with emotions and thoughts; and 4. Have access to a web-enabled device (e.g., smartphone, tablet, laptop, or desktop) with reliable internet access at home or in a public space (e.g., library). Exclusion Criteria (Parents of children with disabilities): 1. Cognitive, physical, sensory impairments, or language barriers (non-English speaking) that would impede participation; 2. Suicidal intent or suicide attempt(s) within the past six months; 3. Participation in another parent support research study at the time of recruitment; or 4. More than three hospitalizations of either the parent or child within the past year, or other serious health concerns that would interfere with program engagement. Inclusion Criteria (Occupational therapists): 1. Be willing to participate in training, program implementation, and study evaluations; and 2. Currently work in a pediatric clinic that serves at least 15 children who attend the clinic at least once per week. Exclusion Criteria (Occupational therapists): N/A

Inclusion Criteria: 1. Age ≥18 and ≤75 years. 2. Eastern Cooperative Oncology Group (ECOG) performance status 0-1. 3. Primary tumor size \>1 cm. 4. Histologically confirmed invasive breast cancer, clinically staged as: * Stage I (T1cN0M0) * Stage II (T1cN1M0, T2N0-1M0 or T3N0M0) * Stage III (T2N2-3M0, T3N1-3M0, or T4N0-3M0) 5. HER2-positive status: IHC 3+ or IHC 2+ with positive ISH. 6. Adequate major organ function: 1. Hematology (no transfusion or hematopoietic growth factors, e.g., G-CSF, within 14 days): * Hemoglobin ≥100 g/L * Absolute neutrophil count (ANC) ≥1.5 × 10⁹/L * Platelet count ≥100 × 10⁹/L 2. Biochemistry: * Total bilirubin ≤1.5 × ULN * ALT and AST ≤1.5 × ULN; ALP ≤2.5 × ULN * BUN and creatinine ≤1.5 × ULN 3. Cardiac function: LVEF ≥55% by echocardiography 7. Women of childbearing potential must have a negative pregnancy test within 7 days prior to enrollment and agree to use effective contraception during the study and for 8 weeks after the last dose. 8. Voluntary written informed consent and willingness to comply with study procedures and follow-up. Exclusion Criteria: 1. Prior anti-tumor therapy for breast cancer, including chemotherapy, radiotherapy, targeted therapy, or endocrine therapy. 2. Concurrent administration of any other anti-tumor treatment. 3. Bilateral breast cancer, inflammatory breast cancer, or occult breast cancer. 4. Breast cancer not confirmed histologically. 5. History of other malignancy within the past 5 years, except successfully treated cervical carcinoma in situ. 6. Severe dysfunction of major organs (heart, liver, kidney). 7. Conditions affecting oral drug administration or absorption, e.g., inability to swallow, chronic diarrhea, or intestinal obstruction. 8. Participation in another investigational drug trial within 4 weeks prior to enrollment. 9. Known hypersensitivity to study drug components; history of immunodeficiency (HIV positive, active HCV, active hepatitis B, other congenital/acquired immunodeficiency) or prior organ transplantation. 10. History of clinically significant cardiac disease, including: 1. Arrhythmia requiring medication 2. Myocardial infarction 3. Heart failure 4. Other cardiac conditions deemed unsuitable for study participation by the investigator 11. Pregnant or breastfeeding women, or women of childbearing potential who test positive at baseline or are unwilling to use effective contraception throughout the study. 12. Any condition that, in the investigator's judgment, poses serious risk to patient safety or may interfere with study completion (e.g., uncontrolled severe hypertension, uncontrolled diabetes, active infection). 13. History of neurological or psychiatric disorders (e.g., epilepsy or dementia) or any other condition the investigator considers incompatible with study participation.

Inclusion Criteria: 1. Women aged 18 - 75 years old; 2. Eastern Cooperative Oncology Group performance status (ECOG-PS) of 0 to 1; 3. Patients with histologically confirmed locally advanced or metastatic breast cancer; 4. Patients with prior adjuvant endocrine resistance following curative-intent surgery; 5. Menstrual status: postmenopausal, perimenopausal, or premenopausal; 6. Presence of evaluable lesions; 7. Organ function must meet required criteria. Exclusion Criteria: 1. Patients with rapidly progressing disease, as judged by the investigator to be unsuitable for endocrine therapy; 2. Patients who have previously received fulvestrant or other novel SERMs (excluding tamoxifen and toremifene); 3. Patients with uncontrolled brain metastases, carcinomatous meningitis, or spinal cord compression; 4. Patients with a history of clinically significant cardiovascular disease; 5. Participants who have not recovered from adverse effects caused by prior therapies; 6. Participants with a history of another malignancy within the past 5 years or currently having another malignancy; 7. Known hypersensitivity to HRS-8080, fulvestrant, dalpiciclib, or any of their components, etc.

Inclusion Criteria: * women who had preeclampsia and women who did not have preeclampsia * 12 weeks to 5 years postpartum * 18-45 years old Exclusion Criteria: * history of hypertension or metabolic disease before pregnancy * history of gestational diabetes * history of gestational hypertension without preeclampsia * skin diseases * current tobacco use * current antihypertensive medication * statin or other cholesterol-lowering medication * currently pregnant * body mass index less than 18.5 kg/m2 * allergy to materials used during the experiment.(e.g. latex), * known allergy to study drugs or salt-supplement

Inclusion Criteria: 1. Subjects who voluntarily sign the Informed Consent Form (ICF), can receive SC injection, fully understand the content, process and possible adverse reactions of the trial, and are able to follow the regulations on contraindications and restrictions specified in this protocol. 2. Male, 18 to 50 years of age at signing the ICF (both inclusive). 3. Weight ≥ 50 kg and body mass index (BMI) within 19-26 kg/m2 (inclusive) at screening. 4. Subjects of childbearing potential with no birth plan from the signing of ICF to 8 weeks after the last dose, willingness to take effective contraceptive measures, and no plan for sperm donation. \- Exclusion Criteria: 1. Subjects with clinically significant abnormalities detected during the screening period in physical examination, vital signs, laboratory tests, 12-lead ECG, abdominal ultrasound, or chest X-ray, as determined by the investigator. 2. Subjects who test positive for hepatitis B virus surface antigen, hepatitis C virus IgG antibody, human immunodeficiency virus antibody, P24 antigen, or anti-treponema pallidum antibody. 3. Subjects with a history of or existing circulatory, urinary, digestive, respiratory, nervous, endocrine, or psychiatric disorders that, in the investigator's judgment, remain clinically significant. 4. History of acute or chronic pancreatitis and pancreatic injury before screening. 5. History or family history of previous or existing medullary thyroid carcinoma, multiple endocrine neoplasia type 2. 6. Subjects who have used any drugs that alter the activity of drug metabolizing enzymes or transporters within 4 weeks prior to screening, or subjects with acute diseases or concomitant medication from the screening period to before randomization. 7. Subjects with severe infection or unexplained infection within 4 weeks before screening. 8. Major surgery within 6 months prior to screening, or scheduled surgery or hospitalization during the study. 9. Subjects known or suspected to have hypersensitivity to any ingredient of the investigational medicinal product (IMP) (glucagon like peptide-1 receptor agonist (GLP-1RA) or its excipients). 10. Use of any prescription drugs, over-the-counter drugs or Chinese herbal medicine within 2 weeks prior to screening; use of any GLP-1R agonists or drugs with the same mechanism of action to GLP-1R agonists (such as GLP-1R/glucagon receptor \[GCGR\] agonists or gastric inhibitory polypeptide receptor \[GIPR\]/GLP-1R agonists or GIPR/GLP-1R/GCGR agonists) within 3 months prior to screening. 11. Subjects who have been vaccinated within 1 month before screening or are scheduled for vaccination during the study. 12. Blood donation or blood loss greater than or equal to 400 mL within 3 months before screening, or blood donation scheduled during the study or within 8 weeks after the end of the study. 13. History of drug abuse prior to screening; or positive results for drug abuse at screening (D-1). 14. History of alcohol abuse within 3 months prior to screening, defined as an average intake of more than 14 units per week (1 standard unit=360 mL of beer or 150 mL of 12% wine or 45 mL of 40% spirits); or use of any alcohol-containing products 48 hours before administration; or abnormal results for breath alcohol test at screening (D-1). 15. Subjects who smoked more than 5 cigarettes per day on average within the 3 months before screening, or who do not agree to abstain from smoking for the duration of the study. 16. Subjects who engage in strenuous exercise within 48 h before administration of the IMP, or have other factors that may affect drug absorption, distribution, metabolism, or excretion. 17. Subjects who consume grapefruit or grapefruit-containing products, or any caffeinated or xanthine-containing foods or beverages (such as coffee, tea, cola, or chocolate) within 48 hours before administration of the IMP. 18. Subjects who have special dietary requirements and cannot adhere to a standardized diet, or who are lactose intolerant. 19. Subjects with a history of needle phobia and blood phobia, difficulty in blood collection or intolerance to venous blood collection. 20. Subjects who are investigators or employees of the study site, or family members of the employees or investigators. 21. Participation in a clinical study of another IMP or device within 3 months before screening, or within 5 half-lives of the previous IMP (whichever is longer). Or plan to participate in another clinical study of an IMP or device before completing all scheduled assessments in the clinical study. \-

Inclusion Criteria: * Provision of written informed consent to participate in the study by the patient or his/her legally authorized representative after receiving and understanding a detailed explanation of the study * Adults aged 70 years or older * Diagnosed with type 2 diabetes or currently receiving antidiabetic medication, without a history or presence of cardiovascular disease * Either: (1) LDL-C≥100 mg/dL if not receiving lipid-lowering therapy, or (2) currently receiving lipid-lowering therapy (in this case, LDL-C level not restricted) Exclusion Criteria: * Diagnosis of type 1 diabetes * Documented history of atherosclerotic cardiovascular disease at screening, confirmed clinically or by imaging: (1) myocardial infarction; (2) coronary revascularization; (3) currently receiving treatment for acute coronary syndrome; (4) history of ischemic stroke; (5) aortic aneurysm; (6) peripheral arterial disease * Currently undergoing cancer treatment * Severe disease requiring recurrent hospitalization * Frailty (defined as a score ≥3 on the Korean FRAIL questionnaire), or any condition significantly limiting self-care * AST or ALT \>3 × ULN, at screening (however, patients will be eligible if repeat testing at the time of randomization shows levels \<3 × ULN), or liver cirrhosis * Contraindications to study drugs * Pregnant or breastfeeding women

Inclusion Criteria: * registered undergraduates aged 18-24 years * own a personal smart device (mobile phone or tablet) * ability to read Chinese * willingness to install the study app and complete the follow-up assessments. Exclusion Criteria: * are on leave of absence or not officially enrolled during the study period * are participating in another mental health intervention program or using similar mental health apps.

Inclusion Criteria: * Singleton pregnancy * High risk for preeclampsia (risk \>1:150) based on FMF screening algorithm combining first-trimester ultrasound, biochemical markers, and medical history * Gestational age \<16 weeks at enrollment * Maternal age ≥18 years * Willing and able to provide written informed consent * Adequate ability for follow-up (direct telephone communication, accessible residence) Exclusion Criteria: * Multiple pregnancy * Current permanent aspirin use for other medical indications * Serious congenital fetal abnormality detected on ultrasound * Contraindication to aspirin or low molecular weight heparin including: known hypersensitivity, active peptic ulcer disease, bleeding disorders or coagulopathy, severe thrombocytopenia (platelet count \<100,000/μL), active or recent significant bleeding, history of heparin-induced thrombocytopenia * Pre-existing severe renal failure (creatinine clearance \<30 mL/min) * Unable to provide informed consent * Low probability of adequate follow-up (residence in remote areas without telephone access, accommodation in temporary structures)

Inclusion Criteria: * Caregivers of children aged 0-4 years diagnosed with a rare genetic disorder. * The child must have been receiving physiotherapy for at least 6 months. * Caregivers who voluntarily agree to participate and provide informed consent. * Caregivers who are able to read and understand Turkish to complete the questionnaires. Exclusion Criteria: * Caregivers who have cognitive or language limitations that prevent them from completing the questionnaires. * Caregivers who decline participation or submit incomplete questionnaire forms. * Children or caregivers with an additional medical or neurological condition that prevents participation in the study.

Inclusion Criteria: * For intervention phase: Individuals aged 20 years and above. For baseline and endline assessments (before and after the intervention): Individuals aged 30 years and above. * Participants residing in the randomized clusters of Kabul, Afghanistan Individuals willing to participate in the study and provide consent. * All individuals with normoglycemia, intermediate hyperglycaemia, and diabetes are encouraged to participate. * Participants who can attend the scheduled meetings and interventions as per the study protocol. Exclusion Criteria: * For Intervention phase: Individuals below the age of 20 years. For baseline and endline assessments (before and after the intervention): individuals below the age of 30 years. * Individuals unwilling to provide consent for participation. * Participants with reported health conditions that may hinder their active involvement in the study. * Individuals with non-compliance with research protocols

Inclusion Criteria: * Adults aged ≥18 years; diagnosis of hypertension in Electronic health record or most recent clinic blood pressure meeting inclusion thresholds (systolic blood pressure ≥130 mmHg and/or diastolic blood pressure ≥80 mmHg); BMI ≥30 kg/m²; able and willing to complete survey instruments and assessment procedures; able to speak/read English; access to a smartphone with text-messaging capability. Exclusion Criteria: * inability to speak/read English; cognitive impairment that precludes informed consent or participation; severe food allergies or medically necessary dietary restrictions that would preclude adoption of a DASH eating pattern; inability to cook at home; current treatment for cancer; self-reported history of a recent major cardiovascular event within the past 12 months (myocardial infarction, cerebrovascular accident, cardiac surgery, or hypertensive emergency); known advanced liver or renal disease; severe mental illness that would preclude participation; pregnancy. Individuals with lactose intolerance will not be excluded because low-lactose alternatives are available within the intervention.