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Inclusion criteria: * Patients with Major Depressive Disorder (MDD), as defined by the DSM-5-TR criteria; * Presence of residual symptoms, defined by a Hamilton Depression Rating Scale score over 7; * Age over 18 years. Exclusion criteria: * MMSE under 18 and/or CDR over 2; * Other neurological diseases (stroke, multiple sclerosis, major head trauma, epilepsy) or psychiatric disorders other than those included (schizophrenia, bipolar disorder, etc.); * Patients with severe clinical conditions, acute or uncontrolled chronic medical diseases; * Endocrine diseases, vitamin deficiencies, or exposure to drugs associated with cognitive impairment and/or mood deflection; * Alcohol abuse or recreational drug use; * Contraindications to MRI and TMS (carriers of implanted devices, patients who have undergone craniotomy, presence of metal fragments or prostheses, history of epilepsy); * Pregnant or breastfeeding women.

Inclusion Criteria: * Being followed up with a diagnosis of Type 2 Diabetes Mellitus for at least 6 months (fasting plasma glucose of 7.0 mmol/L or higher) * Not having participated in any structured exercise program for at least 6 months prior. * Being willing to volunteer for the study Exclusion Criteria: * Nephropathy * Retinopathy * Having dementia or Alzheimer's disease * Using a walking aid * Having ulceration * Using balance-curing drugs * Surviving myocardial infarction at least 6 months ago * Stable or unstable angina pectoris * Left ventricular ejection fraction below 40% * Peripheral arterial diseases * Resting blood pressure above 160/100 mmHg * Body mass index above 35 kg/m2 * Having a history of deep vein thrombosis, pulmonary embolism or stroke in the past

Inclusion Criteria: * Patients of both genders whose age of disease onset was older than 16 years * Patients newly diagnosed with or previously diagnosed with T2D * Able and willing to provide written informed consent and to comply with the study Exclusion Criteria: * Patients with other medical comorbidities (not a complication of diabetes), such as malignancies. * Pregnancy

Inclusion Criteria: 1. Patients with established diagnosis of CTEPH who are symptomatic after Balloon pulmonary angioplasty (BPA) 2. Patients who are on stable maximally tolerated dose of sildenafil for at least 6 weeks as monotherapy, or in combination with other pulmonary hypertension specific therapies 3. WHO functional class III at screening 4. Stable dose of diuretics (if used) for at least 30 days at screening 5. No recent hospitalisation due to pulmonary hypertension or heart failure for at least 30 days Exclusion Criteria: 1. Previous treatment with riociguat other sGCs, or documented severe drug reaction or intolerance to sGCs 2. Use of nitrates or nitric oxide donors (eg, nitroglycerin, amyl nitrite, isosorbide dinitrate etc) by any administration routes within 30 days of screening 3. Pregnant women or breast-feeding women, or women with childbearing potential not using of combination of two effective contraception methods throughout study 4. Renal impairment with glomerular filtration rate \<15mL /min 5. Child-Pugh C hepatic impairment

Inclusion Criteria: * 1.Age ≥ 18 years; 2.Histological and/or cytological diagnosis of breast cancer; 3.Treatment niave patients; 4.To receive standard neoadjuvant therapy; 5.Eastern Cooperative Oncology Group (ECOG) performance status of 0-1; 6.Presence of at least one measurable lesion according to the Response Evaluation Criteria in Advanced Solid Tumors version 1.1 (RECIST v1.1) ; 7.Informed and agreed to participate in the study; Exclusion Criteria: * 1\. Breast cancer has not been confirmed through histological or cytological examinations. 2.Other breast cancer conditions that do not receive neoadjuvant therapy. 3.Combined with other malignant tumors. 4.Concurrent acute or chronic psychiatric disorders, along with having received antidepressant or anti-anxiety therapy within the past month. 5.Participants must not have engaged in any other clinical trials in the past month, unless those trials are observational or non-interventional in nature.

Inclusion Criteria: * Age 40-79 * Presence of clinically-significant anxiety and/or depression (as determined by an eligibility evaluation) * Stroke that occurred 1 month or more prior to study initiation * Capacity to provide consent * No greater than mild cognitive difficulties based on an eligibility evaluation conducted as part of the study * If taking medication for depression and/or anxiety, must be on a stable dose for a minimum of 8 weeks prior to study initiation * Ability to use iPhone or iPad independently * Home internet access * Willingness to participate in the full study duration. Exclusion Criteria: * Aphasia of moderate or greater severity (as determined during an eligibility evaluation) * Non-fluency in English * History of a bipolar or psychotic disorder * Current alcohol or substance use disorder * Active suicidal ideation * Current engagement in psychotherapy is not grounds for exclusion unless the individual's psychotherapy is primarily focused on CBT * Severe depression and/or anxiety based on the initial evaluation and clinical judgment of the study doctor, which warrants a higher level of care and/or immediate referral to psychiatric services * Any other clinical or medical reason in the study doctor's initial screening evaluation that suggests the study is not appropriate for the participant

Inclusion Criteria: * \- Age ≥18 years old. * TYPE 2 DM with or without DF . * Patients are at different stages of CKD as defined according to KDIGO (9). Exclusion Criteria: * \- Patients on dialysis or CKD stage 5 (GFR \< 15 ml/min) * Patients with kidney transplant * Pregnant patients * Type 1 DM

Inclusion Criteria: * Meets the diagnostic criteria for asthma/COPD(Group E in the GOLD classification); ② Age range from18 years to 80 years(asthma) and 40 yesrs to 80 years(COPD); * The investigators agreed to participate in this clinical study by voluntarily signing an informed consent form. Exclusion Criteria: * Patients with other pulmonary diseases (lung abscess, pulmonary interstitial fibrosis, active pulmonary tuberculosis, bronchiectasis，etc); * Patients with severe cardiovascular and cerebrovascular diseases (malignant arrhythmia, unstable angina, acute myocardial infarction, heart grade 3 or above, stroke, cerebral hemorrhage, etc.); * Patients with severe liver diseases (liver cirrhosis, portal hypertension, and caused by esophageal and gastric varices) and severe kidney diseases (dialysis, kidney transplantation, etc.); * Patients with impaired consciousness or various illnesses who cannot communicate normally; ⑤Pregnant and lactating women; ⑥Patients who are participating in other clinical trials within one month prior to enrollment; ⑦Patients who have received acupuncture or other traditional Chinese medicine external treatments within the past year; ⑧ Patients who are allergic to external patches

Inclusion Criteria: * A diagnosis of Depression based on Diagnostic and Statistical Manual (DSM) 5.0 criteria. * Receiving a neuromodulation (rTMS) treatment for depression at the HCN * Physically healthy * Age 18-80, inclusive. * Able to provide informed consent and comply with the study protocol. * Patients will not be excluded solely based on communication (i.e., non-English speaking) unless they have exclusion criteria that is the cause of the communication difficulties. Exclusion Criteria: * Moderate substance use disorder or greater severity based on DSM 5.0 criteria and confirmed by a study MD on clinical assessment. * Mild and major comorbid medical conditions (as determined by investigators - e.g., neurological diseases, uncontrolled hypertension or diabetes, malignancy) * A major comorbid psychiatric disorder (as determined by investigators - e.g., schizophrenia or bipolar disorder) and/or psychosis at the time of study enrollment. * History of seizure disorder * Pregnant

Inclusion Criteria: 1. Men and women aged \&gt; 18 years. 2. For female participants: pre-menopausal, peri-menopausal and post-menopausal women can all be included. 3. Participants willing and able to give informed consent for participation in the study. 4. Healthy controls \&lt;10 pack year history (participants without Asthma or COPD). Exclusion Criteria: 1. Known or suspected current pulmonary tuberculosis, HIV (human immunodeficiency virus), Hepatitis B Virus, Hepatitis C Virus. 2. Alcohol or recreational drug abuse, is defined as when the use is harmful as per NHS definition. 3. History of psychiatric, medical, or surgical disorders. 4. Pregnant 5. Unable to provide written informed consent 6. History of advanced medical conditions with an expected prognosis of \&lt; 3 years. 7. Patients with a history of active cancer. 8. Patients on long term oxygen (ambulatory oxygen).

Inclusion Criteria: 1. "Target partner" is eligible for the National DPP per CDC eligibility requirements: * BMI ≥ 25 kg/m² (≥ 23 kg/m² if Asian American), and * Do not have a diagnosis of type 1 or type 2 diabetes, and * Not currently pregnant, and * High risk for type 2 diabetes based on: (i) CDC Prediabetes Risk Test score ≥ 5, (ii) clinically diagnosed Gestational Diabetes during a previous pregnancy (for women), or (iii) a blood test result indicative of prediabetes in the past year (i.e., fasting blood glucose 100-125 mg/dl; plasma glucose 140-199 mg/dl measured 2 hours after a 75 g glucose load; or HbA1c 5.7%-6.4%). 2. The couple has lived together for 1+ years. 3. Both partners are willing to participate in the research. 4. Both partners are at least 18 years old. 5. Both partners are fluent in English. EXCLUSION CRITERIA: 1. "Supporting partner" has a diagnosis of Type 2 Diabetes. 2. Either partner: * Has a diagnosis of another chronic disease (unless no major events/changes for 3+ months), or * Is currently on medication or engaged in lifestyle intervention for prediabetes or obesity, or * Has previously participated in the National DPP, or * Reports discomfort participating in a lifestyle program with their partner, or * Reports a low level of relationship commitment (i.e., "4" or lower on a scale from 1 (do not agree at all) to 7 (agree completely) on the item "I want this relationship to stay strong no matter what rough times we encounter."; Owen et al., 2011).

Inclusion Criteria: * Diagnosis of SCI according to the International Standards for the Neurological Classification of SCI with confirmation by computed tomography/magnetic resonance imaging; * At least 18 years old; * With stable spinal systems and good vital signs, and currently living in the community and having SCI for more than 6 months; * No contraindications to undergoing MRI examination (e.g., no metal or electronic devices in the body, not pregnant, and absence of claustrophobia); * Having a mobile Internet terminal (usually a smartphone) and proficient independent or caregiver-assisted usage; * Able to communicate in Cantonese and to provide informed consent. Exclusion Criteria: * Having severe problems in hearing, verbal communication, or vision; * Engaged in ongoing psychotherapy or any other physiotherapy/ exercise/ relaxation interventions; * Physically active for more than 150 minutes moderate-intensity exercise per week; * Diagnosis of mental disorders or substance misuse; * With severe cognitive impairment (Hong Kong Montreal Cognitive Assessment (HK-MoCA) score ≤ 18.

Participants will be identified from the SCORE! Cohort study who have previously received a letter indicating their cardiovascular risk score. They are eligible if: Uncontrolled CV risk factors will be defined as follows: * Blood pressure measurements: systolic ≥ 140 or diastolic BP ≥ 90 mm Hg; * Non-HDL cholesterol \&amp;amp;gt; 2.66 mmol/L; * Random plasma glucose of ≥ 11.1 mmol/L or HbA1c% ≥ 6.5% Exclusion criteria include: * Involvement in another study or program that would interfere with the study protocol, * Known history of coronary artery disease or stroke; * Severe co-morbid conditions with life expectancy \< 1 year, * Pregnancy or plans to become pregnant within 12 months; * Other serious conditions or logistic factors likely to interfere with study participation

Inclusion Criteria: 1. asymptomatic Chinese Women 2. 44-69 years old 3. eligible to enroll in a government-subsidized risk-stratified BC screening program 4. ability to read Chinese Exclusion Criteria: 1. moderate- or high-risk women as defined by the local risk-stratified BC screening program 2. inability to provide informed consent 3. incomplete conversation with the chatbot.

Inclusion Criteria: * Treatment with intensive insulin therapy (basal bolus regimen with 3 or more daily doses of insulin). * Perform 6 or more daily capillary glycaemia determinations. * Be willing to use a CGM device for at least 70% of the time. * Undergo training on the use of the CGM device by the centre's CGM referent. * Agree to participate in the study. Exclusion Criteria: * Cognitive impairment measured by Pfeiffer test with a score of 3 or more errors. * Previous use of a CGM device. * Pregnancy. * Being institutionalised. * Having participated in another research study related to diabetes mellitus within the last year. * Not having proper handling of the CGM device: inability to download glycaemic control data, inability to keep the sensor attached to the skin, not understanding how it works, etc.

Inclusion Criteria: * ☑ Have been diagnosed with type 2 diabetes mellitus (T2DM); * Have a BMI ≥23 kilograms per meter squared (kg/m²) at screening; * Be of stable weight (± 5%) for at least 3 months before screening; * Have HbA1c between ≥7.5% and ≤11.0%； * Fasting Plasma Glucose (FPG) ≤ 15.0 mmoL/L. Exclusion Criteria: * ■ Previous diagnosis of type 1 diabetes, special type diabetes ; * There are malignant tumors within 5 years before screening, or patients are in latent of clinical malignant tumors (except patients with skin basal cell carcinoma and squamous cell carcinoma, cervical carcinoma in situ, prostate carcinoma in situ or papillary thyroid carcinoma who have no recurrence after surgery). * Have had chronic or acute pancreatitis any time prior to study entry; * Known allergic constitution (allergy to 3 or more kinds of food or drugs), or allergy to GLP-1 receptor agonists, or severe allergic diseases (asthma, urticaria, eczematous dermatitis, etc.) at screening; * Mentally incapacitated or speech-impaired; * Suspected or confirmed history of alcohol or drug abuse; * Pregnant or lactating woman; * The investigator considers that there are any other conditions that make it inappropriate to participate in this study.

Inclusion Criteria: * Presenting for antenatal care at one of our 5 recruitment sites * ≥ 18 years of age * ≤ 34 weeks gestation * HIV-positive, based on medical records * Initiating, re-initiating, or on established ART during index pregnancy * Elevated depressive symptoms as indicated by a EPDS score ≥10. The EPDS is widely used to assess perinatal mood disorders that has been validated in perinatal populations in Malawi with this cut point to identify probable perinatal depression Exclusion Criteria: * Suicidal ideation evaluated as acute risk. * Other health concerns requiring emergent response.

Inclusion Criteria: * Subjects aged 21 to 85yo * Subjects or witnesses fluent in written and spoken French * Subjects agreeing to attend the study visit and follow study procedures * Subjects that have signed the informed consent form. Exclusion Criteria: * Amputated index fingers * Damaged/injured skin at index fingers * Damaged/injured skin at wrists * Subjects with tachycardia (heart rate at rest \> 120bpm) * Subjects with atrial fibrillation * Subjects with diabetes * Subjects with marked renal dysfunctions (eGFR \< 30mL/min/1.73 m2) * Subjects with untreated hyper-/hypothyroidism * Subjects with pheochromocytoma * Subjects with Raynaud's disease * Subjects with an arteriovenous fistula * Women in known pregnancy * History of polyneuropathy

Inclusion Criteria: 1. Age 40-70 years at time of screening. 2. Both Men and women are included in study. 3. Patients with chronic heart failure and currently categorized in class II-IV heart failure as per NHYA classification having ejection fraction less than 40%. 4. Patients having NT- proBNP levels greater than 25pg/ml. 5. Diabetic patient diagnosed (HbA1c \> 6.5mg/dl) and currently taking antidiabetic medicine. Exclusion Criteria: 1. Pregnant female. 2. Patient with end stage renal disease (ESRD). 3. Patient with acute decompensated heart failure. 4. Acute coronary syndrome patients.

Inclusion Criteria: * diagnosis of MDD * Center for Epidemiological Studies Depression Scale for Children (CESD-C) score ≥ 25 at baseline * access to the internet and a computer or smart phone * presence of a parent who is willing to participate Exclusion Criteria: * adherent to a high-quality diet at baseline * presence of an eating disorder * currently participating in other dietary programs or studies * actively attempting to increase or decrease body weight; * presence of a chronic medical condition; * unstable psychiatric condition (e.g., mania, active suicidal ideation)